Safety and Pharmacokinetics of HTL0018318, a Novel M(1) Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects

por Bakker, Charlotte, van der Aart, Jasper, Labots, Geert, Liptrot, Jan, Cross, David M., Klaassen, Erica S., Dickinson, Steve, Tasker, Tim, Groeneveld, Geert Jan
Publicado 2021

Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine

por Bakker, Charlotte, van der Aart, Jasper, Hart, Ellen P., Klaassen, Erica S., Bergmann, Kirsten R., van Esdonk, Michiel J., Kay, Denis G., Groeneveld, Geert Jan
Publicado 2020

Quantification of human brain PDE4 occupancy by GSK356278: A [(11)C](R)-rolipram PET study

por van der Aart, Jasper, Salinas, Cristian, Dimber, Rahul, Pampols-Maso, Sabina, Weekes, Ashley A, Tonkyn, John, Gray, Frank A, Passchier, Jan, Gunn, Roger N, Rabiner, Eugenii A
Publicado 2017

Brain exposure of osimertinib in patients with epidermal growth factor receptor mutation non‐small cell lung cancer and brain metastases: A positron emission tomography and magneti...

por Ekman, Simon, Cselényi, Zsolt, Varrone, Andrea, Jucaite, Aurelija, Martin, Heather, Schou, Magnus, Johnström, Peter, Laus, Gianluca, Lewensohn, Rolf, Brown, Andrew P., van der Aart, Jasper, Vishwanathan, Karthick, Farde, Lars
Publicado 2023

First in human evaluation of [(18)F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors

por van der Aart, Jasper, Golla, Sandeep S. V., van der Pluijm, Marieke, Schwarte, Lothar A., Schuit, Robert C., Klein, Pieter J., Metaxas, Athanasios, Windhorst, Albert D., Boellaard, Ronald, Lammertsma, Adriaan A., van Berckel, Bart N. M.
Publicado 2018