Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders

por Jiang, Ming, van der Stelt, Mario
Publicado 2018

Chemical Probes to Control and Visualize Lipid Metabolism in the Brain

por Punt, Jeroen M., van der Vliet, Daan, van der Stelt, Mario
Publicado 2022

Discovery of Novel Small Molecule Activators of β-Catenin Signaling

por Verkaar, Folkert, van der Stelt, Mario, Blankesteijn, W. Matthijs, van der Doelen, Antoon A., Zaman, Guido J. R.
Publicado 2011

Protein Dynamics Influence the Enzymatic Activity of Phospholipase A/Acyltransferases 3 and 4

por Chatterjee, Soumya Deep, Zhou, Juan, Dasgupta, Rubin, Cramer-Blok, Anneloes, Timmer, Monika, van der Stelt, Mario, Ubbink, Marcellus
Publicado 2021

Clickable Vitamins as a New Tool to Track Vitamin A and Retinoic Acid in Immune Cells

por Bos, Amelie V., Erkelens, Martje N., Koenders, Sebastiaan T.A., van der Stelt, Mario, van Egmond, Marjolein, Mebius, Reina E.
Publicado 2021

Development of a Multiplexed Activity-Based Protein Profiling Assay to Evaluate Activity of Endocannabinoid Hydrolase Inhibitors

por Janssen, Antonius P. A., van der Vliet, Daan, Bakker, Alexander T., Jiang, Ming, Grimm, Sebastian H., Campiani, Giuseppe, Butini, Stefania, van der Stelt, Mario
Publicado 2018

Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells

por Saliba, Soraya Wilke, Jauch, Hannah, Gargouri, Brahim, Keil, Albrecht, Hurrle, Thomas, Volz, Nicole, Mohr, Florian, van der Stelt, Mario, Bräse, Stefan, Fiebich, Bernd L.
Publicado 2018

Structure Kinetics Relationships and Molecular Dynamics Show Crucial Role for Heterocycle Leaving Group in Irreversible Diacylglycerol Lipase Inhibitors

por Janssen, Antonius P.A., van Hengst, Jacob M.A., Béquignon, Olivier J.M., Deng, Hui, van Westen, Gerard J.P., van der Stelt, Mario
Publicado 2019

Biochemical and Cellular Characterization of the Function of Fluorophosphonate-Binding Hydrolase H (FphH) in Staphylococcus aureus Support a Role in Bacterial Stress Response

por Fellner, Matthias, Walsh, Annabel, Dela Ahator, Stephen, Aftab, Nadia, Sutherland, Ben, Tan, Eng W., Bakker, Alexander T., Martin, Nathaniel I., van der Stelt, Mario, Lentz, Christian S.
Publicado 2023

Structure–Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N-Acylphosphatidylethanolamine Phospholipase D

por Mock, Elliot D., Kotsogianni, Ioli, Driever, Wouter P. F., Fonseca, Carmen S., Vooijs, Jelle M., den Dulk, Hans, van Boeckel, Constant A. A., van der Stelt, Mario
Publicado 2020

Live‐Cell Imaging of Sterculic Acid—a Naturally Occurring 1,2‐Cyclopropene Fatty Acid—by Bioorthogonal Reaction with Turn‐On Tetrazine‐Fluorophore Conjugates

por Bertheussen, Kristine, van de Plassche, Merel, Bakkum, Thomas, Gagestein, Berend, Ttofi, Iakovia, Sarris, Alexi J. C., Overkleeft, Herman S., van der Stelt, Mario, van Kasteren, Sander I.
Publicado 2022

Development of a Cannabinoid-Based Photoaffinity Probe to Determine the Δ(8/9)-Tetrahydrocannabinol Protein Interaction Landscape in Neuroblastoma Cells

por Soethoudt, Marjolein, Alachouzos, Georgios, van Rooden, Eva J., Moya-Garzón, María Dolores, van den Berg, Richard J.B.H.N., Heitman, Laura H., van der Stelt, Mario
Publicado 2018

Inhibition of diacylglycerol lipase β modulates lipid and endocannabinoid levels in the ex vivo human placenta

por Berger, Natascha, van der Wel, Tom, Hirschmugl, Birgit, Baernthaler, Thomas, Gindlhuber, Juergen, Fawzy, Nermeen, Eichmann, Thomas, Birner-Gruenberger, Ruth, Zimmermann, Robert, van der Stelt, Mario, Wadsack, Christian
Publicado 2023

An Affinity-Based Probe for the Human Adenosine A(2A) Receptor

por Yang, Xue, Michiels, Thomas J. M., de Jong, Coen, Soethoudt, Marjolein, Dekker, Niek, Gordon, Euan, van der Stelt, Mario, Heitman, Laura H., van der Es, Daan, IJzerman, Adriaan P.
Publicado 2018

Olaparib‐Based Photoaffinity Probes for PARP‐1 Detection in Living Cells

por Voorneveld, Jim, Florea, Bogdan I., Bakkum, Thomas, Mendowicz, Rafal J., van der Veer, Miriam S., Gagestein, Berend, van Kasteren, Sander I., van der Stelt, Mario, Overkleeft, Herman S., Filippov, Dmitri V.
Publicado 2020

Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE∗3-Leiden.CETP mice

por van Eenige, Robin, Ying, Zhixiong, Tambyrajah, Lauren, Pronk, Amanda C.M., Blomberg, Niek, Giera, Martin, Wang, Yanan, Coskun, Tamer, van der Stelt, Mario, Rensen, Patrick C.N., Kooijman, Sander
Publicado 2021

Chemical Proteomics Reveals Off-Targets of the Anandamide Reuptake Inhibitor WOBE437

por Gagestein, Berend, Stevens, Anna F., Fazio, Domenico, Florea, Bogdan I., van der Wel, Tom, Bakker, Alexander T., Fezza, Filomena, Dulk, Hans den, Overkleeft, Herman S., Maccarrone, Mauro, van der Stelt, Mario
Publicado 2022

Drug Discovery Maps, a Machine Learning Model That Visualizes and Predicts Kinome–Inhibitor Interaction Landscapes

por Janssen, Antonius P. A., Grimm, Sebastian H., Wijdeven, Ruud H. M., Lenselink, Eelke B., Neefjes, Jacques, van Boeckel, Constant A. A., van Westen, Gerard J. P., van der Stelt, Mario
Publicado 2018

Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men

por Kantae, Vasudev, Nahon, Kimberly J., Straat, Maaike E., Bakker, Leontine E. H., Harms, Amy C., van der Stelt, Mario, Hankemeier, Thomas, Jazet, Ingrid M., Boon, Mariëtte R., Rensen, Patrick C. N.
Publicado 2017

ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction

por Baggelaar, Marc P., den Dulk, Hans, Florea, Bogdan I., Fazio, Domenico, Bernabò, Nicola, Raspa, Marcello, Janssen, Antonius P. A., Scavizzi, Ferdinando, Barboni, Barbara, Overkleeft, Hermen S., Maccarrone, Mauro, van der Stelt, Mario
Publicado 2019