Development and Application of a Mechanistic Population Modeling Approach to Describe Abemaciclib Pharmacokinetics

por Chigutsa, Emmanuel, Kambhampati, Siva Rama Prasad, Karen Sykes, Amanda, Posada, Maria M., van der Walt, Jan‐Stefan, Turner, P. Kellie
Publicado 2020

Japanese subgroup analysis of the phase 3 MONARCH 3 study of abemaciclib as initial therapy for patients with hormone receptor-positive, human epidermal growth factor receptor 2-ne...

por Takahashi, Masato, Tokunaga, Eriko, Mori, Joji, Tanizawa, Yoshinori, van der Walt, Jan-Stefan, Kawaguchi, Tsutomu, Goetz, Matthew P., Toi, Masakazu
Publicado 2021

Clinical Pharmacokinetic Studies of Enzalutamide

por Gibbons, Jacqueline A., Ouatas, Taoufik, Krauwinkel, Walter, Ohtsu, Yoshiaki, van der Walt, Jan-Stefan, Beddo, Vanessa, de Vries, Michiel, Mordenti, Joyce
Publicado 2015

Pharmacokinetic Drug Interaction Studies with Enzalutamide

por Gibbons, Jacqueline A., de Vries, Michiel, Krauwinkel, Walter, Ohtsu, Yoshiaki, Noukens, Jan, van der Walt, Jan-Stefan, Mol, Roelof, Mordenti, Joyce, Ouatas, Taoufik
Publicado 2015

Lack of association between stavudine exposure and lipoatrophy, dysglycaemia, hyperlactataemia and hypertriglyceridaemia: a prospective cross sectional study

por Sinxadi, Phumla Z, van der Walt, Jan-Stefan, McIlleron, Helen M, Badri, Motasim, Smith, Peter J, Dave, Joel A, Levitt, Naomi S, Maartens, Gary
Publicado 2010

Japanese subpopulation analysis of MONARCH 2: phase 3 study of abemaciclib plus fulvestrant for treatment of hormone receptor-positive, human epidermal growth factor receptor 2-neg...

por Inoue, Kenichi, Masuda, Norikazu, Iwata, Hiroji, Takahashi, Masato, Ito, Yoshinori, Miyoshi, Yasuo, Nakayama, Takahiro, Mukai, Hirofumi, van der Walt, Jan-Stefan, Mori, Joji, Sakaguchi, Sachi, Kawaguchi, Tsutomu, Tanizawa, Yoshinori, Llombart-Cussac, Antonio, Sledge, George W., Toi, Masakazu
Publicado 2021

A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

por Kierzek, Andrzej M., Hickling, Timothy P., Figueroa, Isabel, Kalvass, J. Cory, Nijsen, Marjoleen, Mohan, Krithika, Veldman, Geertruida M., Yamada, Akihiro, Sayama, Hiroyuki, Yokoo, Sachiko, Gulati, Abhishek, Dhanikula, Renu S., Gokemeijer, Jochem, Leil, Tarek A., Thalhauser, Craig J., Giorgi, Mario, Swat, Maciej J., Chelliah, Vijayalakshmi, Small, Ben G., Benson, Neil, Walker, Michael, Gadkar, Kapil, Quarmby, Valerie, Deng, Rong, Ferrante, Andrea, Dickinson, Gemma L., Van Der Walt, Jan‐Stefan, Zhou, Lian, Chen, Xiaoying, Jones, Hannah M., Narula, Jatin, Tourdot, Sophie, Lavé, Thierry, Ribba, Benjamin, van der Graaf, Piet H.
Publicado 2019