Endotoxins : pyrogens, LAL testing, and depyrogenation /

Detalles Bibliográficos
Autor principal: Williams, Kevin L.
Otros Autores: Weary, Marlys, Jorgensen, James H.
Formato: Libro
Lenguaje:English
Publicado: New York ; Basel : Marcel Dekker, c2001.
Edición:2nd ed., rev. and expanded.
Colección:Drugs and the pharmaceutical sciences ; v. 111
Materias:
Endotoxinas > Análisis.
Pirógenos > Análisis.
Prueba de Limulus.
Drogas > Microbiología.
Tabla de Contenidos:
  • Historical foundations of pyrogen research
  • Pyrogen, endotoxin, and fever: an overview
  • Endotoxin structure, function and activity
  • Host response to endotoxin
  • Nonendotoxin microbial pyrogens: lesser endotoxins, superantigens, and adventitious agents
  • Nonmicrobial exogenous pyrogens and drug fever
  • Pharmaceutical manufacturing contamination control
  • Endotoxin as a standard
  • The rabbit pyrogen test
  • LAL discovery, mechanism, and application
  • LAL assay development, validation, and regulation
  • Automation and viewing kinetic data
  • Prospective tests for endotoxin and other microbial artifacts
  • Depyrogenatin validation, pyroburden, and endotoxin removal from drugs
  • Therapeutic approaches to gram-negative sepsis.

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