Is there a fundamental cosmological dipole?

Early hints for deviation from the cosmological principle and statistical isotropy are being accumulated. After reviewing these hints, I focus on four cosmologically observed axes which appear to be either marginally consistent or in conflict with the standard ΛCDM isotropic and homogeneous cosmology. These axes are abnormally aligned with each other and include: (a) The Fine Structure Constant α Dipole (b) the Dark Energy Dipole (c) the Dark Velocity Flow and (d) the CMB Maximum Temperature Asymmetry. I also discuss a simple physical model (extended topological quintessence) that has the potential to explain the existence and alignment of these axes. The model is based on the recent formation of a global monopole with Hubble scale core by an O(3) symmetric scalar field, non-minimally coupled to electromagnetism.