A comprehensive & systematic study of coincidence time resolution and light yield using scintillators of different size, wrapping and doping

Over the last years interest in using time-of-flight-based Positron Emission Tomography (TOF-PET) systems has significantly increased. High time resolution in such PET systems is a powerful tool to improve signal to noise ratio and therefore to allow smaller exposure rates for patients as well as faster image reconstruction. Improvement in coincidence time resolution (CTR) in PET systems to the level of 200ps FWHM requires the optimization of all parameters in the photon detection chain influencing the time resolution: crystal, photodetector and readout electronics. After reviewing the factors influencing the time resolution of scintillators, we will present in this paper the light yield and CTR obtained for different scintillator types (LSO:Ce, LYSO:Ce, LGSO:Ce, LSO:Ce:0.4Ca, LuAG:Ce, LuAG:Pr) with different cross-sections, lengths and reflectors. Whereas light yield measurements were made with a classical PMT, all CTR tests were performed with Hamamatsu-MPPCs or SiPMs S10931-050P. The CTR measurements were based on the time-over-threshold method in a coincidence setup using the ultra fast amplifier-discriminator chip NINO and a fast oscilloscope. Strong correlations between light yield and CTR were found. Excellent results have been obtained for LYSO crystals of 2×2×10mm3 and LYSO pixels of 0.75×0.75×10mm3 with a CTR of 175ps and 188ps FWHM, respectively.