On the differential structure of metric measure spaces and applications

The main goals of this paper are: (i) To develop an abstract differential calculus on metric measure spaces by investigating the duality relations between differentials and gradients of Sobolev functions. This will be achieved without calling into play any sort of analysis in charts, our assumptions being: the metric space is complete and separable and the measure is Radon and non-negative. (ii) To employ these notions of calculus to provide, via integration by parts, a general definition of distributional Laplacian, thus giving a meaning to an expression like \Delta g=\mu, where g is a functi