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Dose-finding designs for early-phase cancer clinical trials: a brief guidebook to theory and practice

This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monito...

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Detalles Bibliográficos
Autores principales: Daimon, Takashi, Hirakawa, Akihiro, Matsui, Shigeyuki
Lenguaje:eng
Publicado: Springer 2019
Materias:
Acceso en línea:https://dx.doi.org/10.1007/978-4-431-55585-8
http://cds.cern.ch/record/2677965
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author Daimon, Takashi
Hirakawa, Akihiro
Matsui, Shigeyuki
author_facet Daimon, Takashi
Hirakawa, Akihiro
Matsui, Shigeyuki
author_sort Daimon, Takashi
collection CERN
description This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.
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spelling cern-26779652021-04-21T18:24:07Zdoi:10.1007/978-4-431-55585-8http://cds.cern.ch/record/2677965engDaimon, TakashiHirakawa, AkihiroMatsui, ShigeyukiDose-finding designs for early-phase cancer clinical trials: a brief guidebook to theory and practiceMathematical Physics and MathematicsThis book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.Springeroai:cds.cern.ch:26779652019
spellingShingle Mathematical Physics and Mathematics
Daimon, Takashi
Hirakawa, Akihiro
Matsui, Shigeyuki
Dose-finding designs for early-phase cancer clinical trials: a brief guidebook to theory and practice
title Dose-finding designs for early-phase cancer clinical trials: a brief guidebook to theory and practice
title_full Dose-finding designs for early-phase cancer clinical trials: a brief guidebook to theory and practice
title_fullStr Dose-finding designs for early-phase cancer clinical trials: a brief guidebook to theory and practice
title_full_unstemmed Dose-finding designs for early-phase cancer clinical trials: a brief guidebook to theory and practice
title_short Dose-finding designs for early-phase cancer clinical trials: a brief guidebook to theory and practice
title_sort dose-finding designs for early-phase cancer clinical trials: a brief guidebook to theory and practice
topic Mathematical Physics and Mathematics
url https://dx.doi.org/10.1007/978-4-431-55585-8
http://cds.cern.ch/record/2677965
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