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Delivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated Design

The design of a particle therapy system that integrates an innovative beam delivery concept based on a static toroidal gantry and an imaging configuration suitable for beam and online range monitoring is proposed and discussed. Such approach would provide a compact and cost-effective layout, with a...

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Autores principales: Bottura, L, Felcini, E, Ferrero, V, Fiorina, E, Monaco, V, Pennazio, F, de Rijk, G, Cerello, P
Lenguaje:eng
Publicado: 2020
Materias:
Acceso en línea:https://dx.doi.org/10.3389/fphy.2020.566679
http://cds.cern.ch/record/2800197
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author Bottura, L
Felcini, E
Ferrero, V
Fiorina, E
Monaco, V
Pennazio, F
de Rijk, G
Cerello, P
author_facet Bottura, L
Felcini, E
Ferrero, V
Fiorina, E
Monaco, V
Pennazio, F
de Rijk, G
Cerello, P
author_sort Bottura, L
collection CERN
description The design of a particle therapy system that integrates an innovative beam delivery concept based on a static toroidal gantry and an imaging configuration suitable for beam and online range monitoring is proposed and discussed. Such approach would provide a compact and cost-effective layout, with a highly flexible and fast beam delivery, single particle counting capability for fast measurement of beam fluence and position and a precise real time verification of the compliance between the treatment delivery and its prescription. The gantry configuration is discussed, presenting an analysis of the residual magnetic field in the bore and of the feasibility of irradiating a realistic target volume. Moreover, the expected performance of the PET-based range monitor is assessed through Monte Carlo simulations, showing a precision in the reconstruction of the activity distribution from a clinical treatment plan better than the state-of-the-art devices. The feasibility of the proposed design is then discussed through an assessment of the technological improvements required to actually start the construction and commissioning of a system prototype.
id cern-2800197
institution Organización Europea para la Investigación Nuclear
language eng
publishDate 2020
record_format invenio
spelling cern-28001972022-01-25T22:17:01Zdoi:10.3389/fphy.2020.566679http://cds.cern.ch/record/2800197engBottura, LFelcini, EFerrero, VFiorina, EMonaco, VPennazio, Fde Rijk, GCerello, PDelivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated DesignAccelerators and Storage RingsThe design of a particle therapy system that integrates an innovative beam delivery concept based on a static toroidal gantry and an imaging configuration suitable for beam and online range monitoring is proposed and discussed. Such approach would provide a compact and cost-effective layout, with a highly flexible and fast beam delivery, single particle counting capability for fast measurement of beam fluence and position and a precise real time verification of the compliance between the treatment delivery and its prescription. The gantry configuration is discussed, presenting an analysis of the residual magnetic field in the bore and of the feasibility of irradiating a realistic target volume. Moreover, the expected performance of the PET-based range monitor is assessed through Monte Carlo simulations, showing a precision in the reconstruction of the activity distribution from a clinical treatment plan better than the state-of-the-art devices. The feasibility of the proposed design is then discussed through an assessment of the technological improvements required to actually start the construction and commissioning of a system prototype.oai:cds.cern.ch:28001972020
spellingShingle Accelerators and Storage Rings
Bottura, L
Felcini, E
Ferrero, V
Fiorina, E
Monaco, V
Pennazio, F
de Rijk, G
Cerello, P
Delivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated Design
title Delivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated Design
title_full Delivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated Design
title_fullStr Delivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated Design
title_full_unstemmed Delivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated Design
title_short Delivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated Design
title_sort delivery, beam and range monitoring in particle therapy in a highly innovative integrated design
topic Accelerators and Storage Rings
url https://dx.doi.org/10.3389/fphy.2020.566679
http://cds.cern.ch/record/2800197
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