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CERN-MEDICIS: A Review Since Commissioning in 2017

The CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, ha...

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Autores principales: Duchemin, Charlotte, Ramos, Joao P, Stora, Thierry, Ahmed, Essraa, Aubert, Elodie, Audouin, Nadia, Barbero, Ermanno, Barozier, Vincent, Bernardes, Ana-Paula, Bertreix, Philippe, Boscher, Aurore, Bruchertseifer, Frank, Catherall, Richard, Chevallay, Eric, Christodoulou, Pinelopi, Chrysalidis, Katerina, Cocolios, Thomas E, Comte, Jeremie, Crepieux, Bernard, Deschamps, Matthieu, Dockx, Kristof, Dorsival, Alexandre, Fedosseev, Valentin N, Fernier, Pascal, Formento-Cavaier, Robert, El Idrissi, Safouane, Ivanov, Peter, Gadelshin, Vadim M, Gilardoni, Simone, Grenard, Jean-Louis, Haddad, Ferid, Heinke, Reinhard, Juif, Benjamin, Khalid, Umair, Khan, Moazam, Köster, Ulli, Lambert, Laura, Lilli, G, Lunghi, Giacomo, Marsh, Bruce A, Martinez Palenzuela, Yisel, Martins, Renata, Marzari, Stefano, Menaa, Nabil, Michel, Nathalie, Munos, Maxime, Pozzi, Fabio, Riccardi, Francesco, Riegert, Julien, Riggaz, Nicolas, Rinchet, Jean-Yves, Rothe, Sebastian, Russell, Ben, Saury, Christelle, Schneider, Thomas, Stegemann, Simon, Talip, Zeynep, Theis, Christian, Thiboud, Julien, van der Meulen, Nicholas P, van Stenis, Miranda, Vincke, Heinz, Vollaire, Joachim, Vuong, Nhat-Tan, Webster, Benjamin, Wendt, Klaus, Wilkins, Shane G
Lenguaje:eng
Publicado: 2021
Materias:
Acceso en línea:https://dx.doi.org/10.3389/fmed.2021.693682
http://cds.cern.ch/record/2803908
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author Duchemin, Charlotte
Ramos, Joao P
Stora, Thierry
Ahmed, Essraa
Aubert, Elodie
Audouin, Nadia
Barbero, Ermanno
Barozier, Vincent
Bernardes, Ana-Paula
Bertreix, Philippe
Boscher, Aurore
Bruchertseifer, Frank
Catherall, Richard
Chevallay, Eric
Christodoulou, Pinelopi
Chrysalidis, Katerina
Cocolios, Thomas E
Comte, Jeremie
Crepieux, Bernard
Deschamps, Matthieu
Dockx, Kristof
Dorsival, Alexandre
Fedosseev, Valentin N
Fernier, Pascal
Formento-Cavaier, Robert
El Idrissi, Safouane
Ivanov, Peter
Gadelshin, Vadim M
Gilardoni, Simone
Grenard, Jean-Louis
Haddad, Ferid
Heinke, Reinhard
Juif, Benjamin
Khalid, Umair
Khan, Moazam
Köster, Ulli
Lambert, Laura
Lilli, G
Lunghi, Giacomo
Marsh, Bruce A
Martinez Palenzuela, Yisel
Martins, Renata
Marzari, Stefano
Menaa, Nabil
Michel, Nathalie
Munos, Maxime
Pozzi, Fabio
Riccardi, Francesco
Riegert, Julien
Riggaz, Nicolas
Rinchet, Jean-Yves
Rothe, Sebastian
Russell, Ben
Saury, Christelle
Schneider, Thomas
Stegemann, Simon
Talip, Zeynep
Theis, Christian
Thiboud, Julien
van der Meulen, Nicholas P
van Stenis, Miranda
Vincke, Heinz
Vollaire, Joachim
Vuong, Nhat-Tan
Webster, Benjamin
Wendt, Klaus
Wilkins, Shane G
author_facet Duchemin, Charlotte
Ramos, Joao P
Stora, Thierry
Ahmed, Essraa
Aubert, Elodie
Audouin, Nadia
Barbero, Ermanno
Barozier, Vincent
Bernardes, Ana-Paula
Bertreix, Philippe
Boscher, Aurore
Bruchertseifer, Frank
Catherall, Richard
Chevallay, Eric
Christodoulou, Pinelopi
Chrysalidis, Katerina
Cocolios, Thomas E
Comte, Jeremie
Crepieux, Bernard
Deschamps, Matthieu
Dockx, Kristof
Dorsival, Alexandre
Fedosseev, Valentin N
Fernier, Pascal
Formento-Cavaier, Robert
El Idrissi, Safouane
Ivanov, Peter
Gadelshin, Vadim M
Gilardoni, Simone
Grenard, Jean-Louis
Haddad, Ferid
Heinke, Reinhard
Juif, Benjamin
Khalid, Umair
Khan, Moazam
Köster, Ulli
Lambert, Laura
Lilli, G
Lunghi, Giacomo
Marsh, Bruce A
Martinez Palenzuela, Yisel
Martins, Renata
Marzari, Stefano
Menaa, Nabil
Michel, Nathalie
Munos, Maxime
Pozzi, Fabio
Riccardi, Francesco
Riegert, Julien
Riggaz, Nicolas
Rinchet, Jean-Yves
Rothe, Sebastian
Russell, Ben
Saury, Christelle
Schneider, Thomas
Stegemann, Simon
Talip, Zeynep
Theis, Christian
Thiboud, Julien
van der Meulen, Nicholas P
van Stenis, Miranda
Vincke, Heinz
Vollaire, Joachim
Vuong, Nhat-Tan
Webster, Benjamin
Wendt, Klaus
Wilkins, Shane G
author_sort Duchemin, Charlotte
collection CERN
description The CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientific program of this unique installation and evaluate the needs of the community to improve the research in imaging, diagnostics, radiation therapy and personalized medicine. The facility has been built as an extension of the ISOLDE (Isotope Separator On Line DEvice) facility at CERN. Handling of open radioisotope sources is made possible thanks to its Radiological Controlled Area and laboratory. Targets are being irradiated by the 1.4 GeV proton beam delivered by the CERN Proton Synchrotron Booster (PSB) on a station placed between the High Resolution Separator (HRS) ISOLDE target station and its beam dump. Irradiated target materials are also received from external institutes to undergo mass separation at CERN-MEDICIS. All targets are handled via a remote handling system and exploited on a dedicated isotope separator beamline. To allow for the release and collection of a specific radionuclide of medical interest, each target is heated to temperatures of up to 2,300°C. The created ions are extracted and accelerated to an energy up to 60 kV, and the beam steered through an off-line sector field magnet mass separator. This is followed by the extraction of the radionuclide of interest through mass separation and its subsequent implantation into a collection foil. In addition, the MELISSA (MEDICIS Laser Ion Source Setup At CERN) laser laboratory, in service since April 2019, helps to increase the separation efficiency and the selectivity. After collection, the implanted radionuclides are dispatched to the biomedical research centers, participating in the CERN-MEDICIS collaboration, for Research & Development in imaging or treatment. Since its commissioning, the CERN-MEDICIS facility has provided its partner institutes with non-conventional medical radionuclides such as Tb-149, Tb-152, Tb-155, Sm-153, Tm-165, Tm-167, Er-169, Yb-175, and Ac-225 with a high specific activity. This article provides a review of the achievements and milestones of CERN-MEDICIS since it has produced its first radioactive isotope in December 2017, with a special focus on its most recent operation in 2020.
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institution Organización Europea para la Investigación Nuclear
language eng
publishDate 2021
record_format invenio
spelling cern-28039082022-04-26T18:29:57Zdoi:10.3389/fmed.2021.693682http://cds.cern.ch/record/2803908engDuchemin, CharlotteRamos, Joao PStora, ThierryAhmed, EssraaAubert, ElodieAudouin, NadiaBarbero, ErmannoBarozier, VincentBernardes, Ana-PaulaBertreix, PhilippeBoscher, AuroreBruchertseifer, FrankCatherall, RichardChevallay, EricChristodoulou, PinelopiChrysalidis, KaterinaCocolios, Thomas EComte, JeremieCrepieux, BernardDeschamps, MatthieuDockx, KristofDorsival, AlexandreFedosseev, Valentin NFernier, PascalFormento-Cavaier, RobertEl Idrissi, SafouaneIvanov, PeterGadelshin, Vadim MGilardoni, SimoneGrenard, Jean-LouisHaddad, FeridHeinke, ReinhardJuif, BenjaminKhalid, UmairKhan, MoazamKöster, UlliLambert, LauraLilli, GLunghi, GiacomoMarsh, Bruce AMartinez Palenzuela, YiselMartins, RenataMarzari, StefanoMenaa, NabilMichel, NathalieMunos, MaximePozzi, FabioRiccardi, FrancescoRiegert, JulienRiggaz, NicolasRinchet, Jean-YvesRothe, SebastianRussell, BenSaury, ChristelleSchneider, ThomasStegemann, SimonTalip, ZeynepTheis, ChristianThiboud, Julienvan der Meulen, Nicholas Pvan Stenis, MirandaVincke, HeinzVollaire, JoachimVuong, Nhat-TanWebster, BenjaminWendt, KlausWilkins, Shane GCERN-MEDICIS: A Review Since Commissioning in 2017Nuclear Physics - ExperimentThe CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientific program of this unique installation and evaluate the needs of the community to improve the research in imaging, diagnostics, radiation therapy and personalized medicine. The facility has been built as an extension of the ISOLDE (Isotope Separator On Line DEvice) facility at CERN. Handling of open radioisotope sources is made possible thanks to its Radiological Controlled Area and laboratory. Targets are being irradiated by the 1.4 GeV proton beam delivered by the CERN Proton Synchrotron Booster (PSB) on a station placed between the High Resolution Separator (HRS) ISOLDE target station and its beam dump. Irradiated target materials are also received from external institutes to undergo mass separation at CERN-MEDICIS. All targets are handled via a remote handling system and exploited on a dedicated isotope separator beamline. To allow for the release and collection of a specific radionuclide of medical interest, each target is heated to temperatures of up to 2,300°C. The created ions are extracted and accelerated to an energy up to 60 kV, and the beam steered through an off-line sector field magnet mass separator. This is followed by the extraction of the radionuclide of interest through mass separation and its subsequent implantation into a collection foil. In addition, the MELISSA (MEDICIS Laser Ion Source Setup At CERN) laser laboratory, in service since April 2019, helps to increase the separation efficiency and the selectivity. After collection, the implanted radionuclides are dispatched to the biomedical research centers, participating in the CERN-MEDICIS collaboration, for Research & Development in imaging or treatment. Since its commissioning, the CERN-MEDICIS facility has provided its partner institutes with non-conventional medical radionuclides such as Tb-149, Tb-152, Tb-155, Sm-153, Tm-165, Tm-167, Er-169, Yb-175, and Ac-225 with a high specific activity. This article provides a review of the achievements and milestones of CERN-MEDICIS since it has produced its first radioactive isotope in December 2017, with a special focus on its most recent operation in 2020.oai:cds.cern.ch:28039082021
spellingShingle Nuclear Physics - Experiment
Duchemin, Charlotte
Ramos, Joao P
Stora, Thierry
Ahmed, Essraa
Aubert, Elodie
Audouin, Nadia
Barbero, Ermanno
Barozier, Vincent
Bernardes, Ana-Paula
Bertreix, Philippe
Boscher, Aurore
Bruchertseifer, Frank
Catherall, Richard
Chevallay, Eric
Christodoulou, Pinelopi
Chrysalidis, Katerina
Cocolios, Thomas E
Comte, Jeremie
Crepieux, Bernard
Deschamps, Matthieu
Dockx, Kristof
Dorsival, Alexandre
Fedosseev, Valentin N
Fernier, Pascal
Formento-Cavaier, Robert
El Idrissi, Safouane
Ivanov, Peter
Gadelshin, Vadim M
Gilardoni, Simone
Grenard, Jean-Louis
Haddad, Ferid
Heinke, Reinhard
Juif, Benjamin
Khalid, Umair
Khan, Moazam
Köster, Ulli
Lambert, Laura
Lilli, G
Lunghi, Giacomo
Marsh, Bruce A
Martinez Palenzuela, Yisel
Martins, Renata
Marzari, Stefano
Menaa, Nabil
Michel, Nathalie
Munos, Maxime
Pozzi, Fabio
Riccardi, Francesco
Riegert, Julien
Riggaz, Nicolas
Rinchet, Jean-Yves
Rothe, Sebastian
Russell, Ben
Saury, Christelle
Schneider, Thomas
Stegemann, Simon
Talip, Zeynep
Theis, Christian
Thiboud, Julien
van der Meulen, Nicholas P
van Stenis, Miranda
Vincke, Heinz
Vollaire, Joachim
Vuong, Nhat-Tan
Webster, Benjamin
Wendt, Klaus
Wilkins, Shane G
CERN-MEDICIS: A Review Since Commissioning in 2017
title CERN-MEDICIS: A Review Since Commissioning in 2017
title_full CERN-MEDICIS: A Review Since Commissioning in 2017
title_fullStr CERN-MEDICIS: A Review Since Commissioning in 2017
title_full_unstemmed CERN-MEDICIS: A Review Since Commissioning in 2017
title_short CERN-MEDICIS: A Review Since Commissioning in 2017
title_sort cern-medicis: a review since commissioning in 2017
topic Nuclear Physics - Experiment
url https://dx.doi.org/10.3389/fmed.2021.693682
http://cds.cern.ch/record/2803908
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