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CXCL$_{10}$ Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study

Chemokines are involved in the remodeling of the heart; however, their significance as biomarkers in heart failure is unknown. We observed that circulating CXCR3 receptor chemokines CXCL9 and CXCL10 in a rat model of heart failure were increased 1 week after myocardial infarction. CXCL10 was also in...

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Detalles Bibliográficos
Autores principales: Altara, Raffaele, Manca, Marco, Hessel, Marleen H, Gu, Yumei, van Vark, Laura C, Akkerhuis, K Martijn, Staessen, Jan A, Struijker-Boudier, Harry A J, Booz, George W, Blankesteijn, W Matthijs
Lenguaje:eng
Publicado: 2016
Materias:
Acceso en línea:https://dx.doi.org/10.1007/s12265-016-9703-3
http://cds.cern.ch/record/2268411
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author Altara, Raffaele
Manca, Marco
Hessel, Marleen H
Gu, Yumei
van Vark, Laura C
Akkerhuis, K Martijn
Staessen, Jan A
Struijker-Boudier, Harry A J
Booz, George W
Blankesteijn, W Matthijs
author_facet Altara, Raffaele
Manca, Marco
Hessel, Marleen H
Gu, Yumei
van Vark, Laura C
Akkerhuis, K Martijn
Staessen, Jan A
Struijker-Boudier, Harry A J
Booz, George W
Blankesteijn, W Matthijs
author_sort Altara, Raffaele
collection CERN
description Chemokines are involved in the remodeling of the heart; however, their significance as biomarkers in heart failure is unknown. We observed that circulating CXCR3 receptor chemokines CXCL9 and CXCL10 in a rat model of heart failure were increased 1 week after myocardial infarction. CXCL10 was also increased in both remote and infarcted regions of the heart and remained elevated at 16 weeks; CXCL9 was elevated in the remote area at 1 week. In humans, hierarchical clustering and principal component analysis revealed that circulating CXCL10, MIP-1α, and CD40 ligand were the best indicators for differentiating healthy and heart failure subjects. Serum CXCL10 levels were increased in patients with symptomatic heart failure as indexed by NYHA classification II through IV. The presence of CXCL10, MIP-1α, and CD40 ligand appears to be dominant in patients with advanced heart failure. These findings identify a distinct profile of inflammatory mediators in heart failure patients
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institution Organización Europea para la Investigación Nuclear
language eng
publishDate 2016
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spelling oai-inspirehep.net-16039332019-09-30T06:29:59Zdoi:10.1007/s12265-016-9703-3http://cds.cern.ch/record/2268411engAltara, RaffaeleManca, MarcoHessel, Marleen HGu, Yumeivan Vark, Laura CAkkerhuis, K MartijnStaessen, Jan AStruijker-Boudier, Harry A JBooz, George WBlankesteijn, W MatthijsCXCL$_{10}$ Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot StudyOtherChemokines are involved in the remodeling of the heart; however, their significance as biomarkers in heart failure is unknown. We observed that circulating CXCR3 receptor chemokines CXCL9 and CXCL10 in a rat model of heart failure were increased 1 week after myocardial infarction. CXCL10 was also increased in both remote and infarcted regions of the heart and remained elevated at 16 weeks; CXCL9 was elevated in the remote area at 1 week. In humans, hierarchical clustering and principal component analysis revealed that circulating CXCL10, MIP-1α, and CD40 ligand were the best indicators for differentiating healthy and heart failure subjects. Serum CXCL10 levels were increased in patients with symptomatic heart failure as indexed by NYHA classification II through IV. The presence of CXCL10, MIP-1α, and CD40 ligand appears to be dominant in patients with advanced heart failure. These findings identify a distinct profile of inflammatory mediators in heart failure patientsoai:inspirehep.net:16039332016
spellingShingle Other
Altara, Raffaele
Manca, Marco
Hessel, Marleen H
Gu, Yumei
van Vark, Laura C
Akkerhuis, K Martijn
Staessen, Jan A
Struijker-Boudier, Harry A J
Booz, George W
Blankesteijn, W Matthijs
CXCL$_{10}$ Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study
title CXCL$_{10}$ Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study
title_full CXCL$_{10}$ Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study
title_fullStr CXCL$_{10}$ Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study
title_full_unstemmed CXCL$_{10}$ Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study
title_short CXCL$_{10}$ Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study
title_sort cxcl$_{10}$ is a circulating inflammatory marker in patients with advanced heart failure: a pilot study
topic Other
url https://dx.doi.org/10.1007/s12265-016-9703-3
http://cds.cern.ch/record/2268411
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