Effect of blackberry juice on swimming patterns and number of neurons in the cg1 region of Wistar Rats

Stress can predispose to the development of psychiatric disorders such as depression. Berry consumption has been associated with a lower risk of developing depression, due to its high content of polyphenols and anthocyanins. This study evaluated the effect of blackberry juice on depression-like behavior and the number of neurons in the Cg1 region of the prefrontal cortex of rats. Forty-four male Wistar rats were divided into five groups: vehicle, low and high blackberry, fluoxetine and diazepam. The effects were evaluated in the open field and forced swimming tests. The histological analysis was performed using the stain cresyl violet. Groups treated with the high dose of blackberry showed antidepressant-like effects, as well as a greater number of neurons in the Cg1 region. Results suggest that blackberry juice could prevent psychiatric disorders associated with stress.