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Peritumoral ADC Values Correlate with the MGMT Methylation Status in Patients with Glioblastoma

SIMPLE SUMMARY: MGMT-methylated glioblastomas have significantly lower ADC values, as compared to the glioblastomas with no MGMT methylation in peritumoral white matter. There were no differences in enhancing tumor areas. These findings could improve predictions of MGMT status in glioblastomas. ABST...

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Autores principales: Ladenhauf, Valentin Karl, Galijasevic, Malik, Kerschbaumer, Johannes, Freyschlag, Christian Franz, Nowosielski, Martha, Birkl-Toeglhofer, Anna Maria, Haybaeck, Johannes, Gizewski, Elke Ruth, Mangesius, Stephanie, Grams, Astrid Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000073/
https://www.ncbi.nlm.nih.gov/pubmed/36900177
http://dx.doi.org/10.3390/cancers15051384
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author Ladenhauf, Valentin Karl
Galijasevic, Malik
Kerschbaumer, Johannes
Freyschlag, Christian Franz
Nowosielski, Martha
Birkl-Toeglhofer, Anna Maria
Haybaeck, Johannes
Gizewski, Elke Ruth
Mangesius, Stephanie
Grams, Astrid Ellen
author_facet Ladenhauf, Valentin Karl
Galijasevic, Malik
Kerschbaumer, Johannes
Freyschlag, Christian Franz
Nowosielski, Martha
Birkl-Toeglhofer, Anna Maria
Haybaeck, Johannes
Gizewski, Elke Ruth
Mangesius, Stephanie
Grams, Astrid Ellen
author_sort Ladenhauf, Valentin Karl
collection PubMed
description SIMPLE SUMMARY: MGMT-methylated glioblastomas have significantly lower ADC values, as compared to the glioblastomas with no MGMT methylation in peritumoral white matter. There were no differences in enhancing tumor areas. These findings could improve predictions of MGMT status in glioblastomas. ABSTRACT: Different results have been reported concerning the relationship of the apparent diffusion coefficient (ADC) values and the status of methylation as the promoter gene for the enzyme methylguanine-DNA methyltransferase (MGMT) in patients with glioblastomas (GBs). The aim of this study was to investigate if there were correlations between the ADC values of the enhancing tumor and peritumoral areas of GBs and the MGMT methylation status. In this retrospective study, we included 42 patients with newly diagnosed unilocular GB with one MRI study prior to any treatment and histopathological data. After co-registration of ADC maps with T1-weighted sequences after contrast administration and dynamic susceptibility contrast (DSC) perfusion, we manually selected one region-of-interest (ROI) in the enhancing and perfused tumor and one ROI in the peritumoral white matter. Both ROIs were mirrored in the healthy hemisphere for normalization. In the peritumoral white matter, absolute and normalized ADC values were significantly higher in patients with MGMT-unmethylated tumors, as compared to patients with MGMT-methylated tumors (absolute values p = 0.002, normalized p = 0.0007). There were no significant differences in the enhancing tumor parts. The ADC values in the peritumoral region correlated with MGMT methylation status, confirmed by normalized ADC values. In contrast to other studies, we could not find a correlation between the ADC values or the normalized ADC values and the MGMT methylation status in the enhancing tumor parts.
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spelling pubmed-100000732023-03-11 Peritumoral ADC Values Correlate with the MGMT Methylation Status in Patients with Glioblastoma Ladenhauf, Valentin Karl Galijasevic, Malik Kerschbaumer, Johannes Freyschlag, Christian Franz Nowosielski, Martha Birkl-Toeglhofer, Anna Maria Haybaeck, Johannes Gizewski, Elke Ruth Mangesius, Stephanie Grams, Astrid Ellen Cancers (Basel) Article SIMPLE SUMMARY: MGMT-methylated glioblastomas have significantly lower ADC values, as compared to the glioblastomas with no MGMT methylation in peritumoral white matter. There were no differences in enhancing tumor areas. These findings could improve predictions of MGMT status in glioblastomas. ABSTRACT: Different results have been reported concerning the relationship of the apparent diffusion coefficient (ADC) values and the status of methylation as the promoter gene for the enzyme methylguanine-DNA methyltransferase (MGMT) in patients with glioblastomas (GBs). The aim of this study was to investigate if there were correlations between the ADC values of the enhancing tumor and peritumoral areas of GBs and the MGMT methylation status. In this retrospective study, we included 42 patients with newly diagnosed unilocular GB with one MRI study prior to any treatment and histopathological data. After co-registration of ADC maps with T1-weighted sequences after contrast administration and dynamic susceptibility contrast (DSC) perfusion, we manually selected one region-of-interest (ROI) in the enhancing and perfused tumor and one ROI in the peritumoral white matter. Both ROIs were mirrored in the healthy hemisphere for normalization. In the peritumoral white matter, absolute and normalized ADC values were significantly higher in patients with MGMT-unmethylated tumors, as compared to patients with MGMT-methylated tumors (absolute values p = 0.002, normalized p = 0.0007). There were no significant differences in the enhancing tumor parts. The ADC values in the peritumoral region correlated with MGMT methylation status, confirmed by normalized ADC values. In contrast to other studies, we could not find a correlation between the ADC values or the normalized ADC values and the MGMT methylation status in the enhancing tumor parts. MDPI 2023-02-22 /pmc/articles/PMC10000073/ /pubmed/36900177 http://dx.doi.org/10.3390/cancers15051384 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ladenhauf, Valentin Karl
Galijasevic, Malik
Kerschbaumer, Johannes
Freyschlag, Christian Franz
Nowosielski, Martha
Birkl-Toeglhofer, Anna Maria
Haybaeck, Johannes
Gizewski, Elke Ruth
Mangesius, Stephanie
Grams, Astrid Ellen
Peritumoral ADC Values Correlate with the MGMT Methylation Status in Patients with Glioblastoma
title Peritumoral ADC Values Correlate with the MGMT Methylation Status in Patients with Glioblastoma
title_full Peritumoral ADC Values Correlate with the MGMT Methylation Status in Patients with Glioblastoma
title_fullStr Peritumoral ADC Values Correlate with the MGMT Methylation Status in Patients with Glioblastoma
title_full_unstemmed Peritumoral ADC Values Correlate with the MGMT Methylation Status in Patients with Glioblastoma
title_short Peritumoral ADC Values Correlate with the MGMT Methylation Status in Patients with Glioblastoma
title_sort peritumoral adc values correlate with the mgmt methylation status in patients with glioblastoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000073/
https://www.ncbi.nlm.nih.gov/pubmed/36900177
http://dx.doi.org/10.3390/cancers15051384
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