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Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma
SIMPLE SUMMARY: Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive blood cancer with poor survival rates, particularly for patients with advanced-stage and relapsed disease. Emerging research on the genetic and molecular causes of ENKTL have revealed new potential treatment strategies. In this r...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000128/ https://www.ncbi.nlm.nih.gov/pubmed/36900160 http://dx.doi.org/10.3390/cancers15051366 |
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author | Major, Ajay Porcu, Pierluigi Haverkos, Bradley M. |
author_facet | Major, Ajay Porcu, Pierluigi Haverkos, Bradley M. |
author_sort | Major, Ajay |
collection | PubMed |
description | SIMPLE SUMMARY: Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive blood cancer with poor survival rates, particularly for patients with advanced-stage and relapsed disease. Emerging research on the genetic and molecular causes of ENKTL have revealed new potential treatment strategies. In this review, we summarize how research on the biological causes of ENKTL has translated to new targets for the treatment of ENKTL, as well as the identification of new bi-omarkers which may predict prognosis and responses to specific anti-cancer therapies and enable a personalized medicine approach towards ENKTL therapy. ABSTRACT: Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive extranodal non-Hodgkin lymphoma (NHL) with poor outcomes, particularly in advanced-stage and relapsed/refractory disease. Emerging research on molecular drivers of ENKTL lymphomagenesis by next-generation and whole genome sequencing has revealed diverse genomic mutations in multiple signaling pathways, with the identification of multiple putative targets for novel therapeutic agents. In this review, we summarize the biological underpinnings of newly-understood therapeutic targets in ENKTL with a focus on translational implications, including epigenetic and histone regulatory aberrations, activation of cell proliferation signaling pathways, suppression of apoptosis and tumor suppressor genes, changes in the tumor microenvironment, and EBV-mediated oncogenesis. In addition, we highlight prognostic and predictive biomarkers which may enable a personalized medicine approach toward ENKTL therapy. |
format | Online Article Text |
id | pubmed-10000128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100001282023-03-11 Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma Major, Ajay Porcu, Pierluigi Haverkos, Bradley M. Cancers (Basel) Review SIMPLE SUMMARY: Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive blood cancer with poor survival rates, particularly for patients with advanced-stage and relapsed disease. Emerging research on the genetic and molecular causes of ENKTL have revealed new potential treatment strategies. In this review, we summarize how research on the biological causes of ENKTL has translated to new targets for the treatment of ENKTL, as well as the identification of new bi-omarkers which may predict prognosis and responses to specific anti-cancer therapies and enable a personalized medicine approach towards ENKTL therapy. ABSTRACT: Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive extranodal non-Hodgkin lymphoma (NHL) with poor outcomes, particularly in advanced-stage and relapsed/refractory disease. Emerging research on molecular drivers of ENKTL lymphomagenesis by next-generation and whole genome sequencing has revealed diverse genomic mutations in multiple signaling pathways, with the identification of multiple putative targets for novel therapeutic agents. In this review, we summarize the biological underpinnings of newly-understood therapeutic targets in ENKTL with a focus on translational implications, including epigenetic and histone regulatory aberrations, activation of cell proliferation signaling pathways, suppression of apoptosis and tumor suppressor genes, changes in the tumor microenvironment, and EBV-mediated oncogenesis. In addition, we highlight prognostic and predictive biomarkers which may enable a personalized medicine approach toward ENKTL therapy. MDPI 2023-02-21 /pmc/articles/PMC10000128/ /pubmed/36900160 http://dx.doi.org/10.3390/cancers15051366 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Major, Ajay Porcu, Pierluigi Haverkos, Bradley M. Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma |
title | Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma |
title_full | Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma |
title_fullStr | Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma |
title_full_unstemmed | Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma |
title_short | Rational Targets of Therapy in Extranodal NK/T-Cell Lymphoma |
title_sort | rational targets of therapy in extranodal nk/t-cell lymphoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000128/ https://www.ncbi.nlm.nih.gov/pubmed/36900160 http://dx.doi.org/10.3390/cancers15051366 |
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