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Research Progress on Glycoprotein 5 of Porcine Reproductive and Respiratory Syndrome Virus

SIMPLE SUMMARY: Research on GP5 protein is of great significance in the diagnosis, prevention, and control of porcine reproductive and respiratory syndrome virus (PRRSV). We summarize its genetic variation, immunity, replication, apoptosis, virulence, interaction with viral protein and host proteins...

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Autores principales: Luo, Qin, Zheng, Yajie, Zhang, Hang, Yang, Zhiyu, Sha, Huiyang, Kong, Weili, Zhao, Mengmeng, Wang, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000246/
https://www.ncbi.nlm.nih.gov/pubmed/36899670
http://dx.doi.org/10.3390/ani13050813
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author Luo, Qin
Zheng, Yajie
Zhang, Hang
Yang, Zhiyu
Sha, Huiyang
Kong, Weili
Zhao, Mengmeng
Wang, Nina
author_facet Luo, Qin
Zheng, Yajie
Zhang, Hang
Yang, Zhiyu
Sha, Huiyang
Kong, Weili
Zhao, Mengmeng
Wang, Nina
author_sort Luo, Qin
collection PubMed
description SIMPLE SUMMARY: Research on GP5 protein is of great significance in the diagnosis, prevention, and control of porcine reproductive and respiratory syndrome virus (PRRSV). We summarize its genetic variation, immunity, replication, apoptosis, virulence, interaction with viral protein and host proteins, which provides a theoretical foundation for exploring the PRRSV replication mechanisms and developing new vaccines. ABSTRACT: Porcine reproductive and respiratory syndrome (PRRS) is an acute, febrile, and highly contagious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV). Glycoprotein 5 (GP5) is a glycosylated envelope protein encoded by the PRRSV ORF5, which has good immunogenicity and can induce the body to produce neutralizing antibodies. Therefore, study of GP5 protein is of great significance in the diagnosis, prevention, and control of PRRSV and the development of new vaccines. We reviewed GP5 protein genetic variation, immune function, interaction with viral protein and host proteins, induction of cell apoptosis, and stimulation of neutralizing antibodies. GP5 protein’s influence on virus replication and virulence, as well as its use as a target for viral detection and immunization are reviewed.
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spelling pubmed-100002462023-03-11 Research Progress on Glycoprotein 5 of Porcine Reproductive and Respiratory Syndrome Virus Luo, Qin Zheng, Yajie Zhang, Hang Yang, Zhiyu Sha, Huiyang Kong, Weili Zhao, Mengmeng Wang, Nina Animals (Basel) Review SIMPLE SUMMARY: Research on GP5 protein is of great significance in the diagnosis, prevention, and control of porcine reproductive and respiratory syndrome virus (PRRSV). We summarize its genetic variation, immunity, replication, apoptosis, virulence, interaction with viral protein and host proteins, which provides a theoretical foundation for exploring the PRRSV replication mechanisms and developing new vaccines. ABSTRACT: Porcine reproductive and respiratory syndrome (PRRS) is an acute, febrile, and highly contagious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV). Glycoprotein 5 (GP5) is a glycosylated envelope protein encoded by the PRRSV ORF5, which has good immunogenicity and can induce the body to produce neutralizing antibodies. Therefore, study of GP5 protein is of great significance in the diagnosis, prevention, and control of PRRSV and the development of new vaccines. We reviewed GP5 protein genetic variation, immune function, interaction with viral protein and host proteins, induction of cell apoptosis, and stimulation of neutralizing antibodies. GP5 protein’s influence on virus replication and virulence, as well as its use as a target for viral detection and immunization are reviewed. MDPI 2023-02-23 /pmc/articles/PMC10000246/ /pubmed/36899670 http://dx.doi.org/10.3390/ani13050813 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Luo, Qin
Zheng, Yajie
Zhang, Hang
Yang, Zhiyu
Sha, Huiyang
Kong, Weili
Zhao, Mengmeng
Wang, Nina
Research Progress on Glycoprotein 5 of Porcine Reproductive and Respiratory Syndrome Virus
title Research Progress on Glycoprotein 5 of Porcine Reproductive and Respiratory Syndrome Virus
title_full Research Progress on Glycoprotein 5 of Porcine Reproductive and Respiratory Syndrome Virus
title_fullStr Research Progress on Glycoprotein 5 of Porcine Reproductive and Respiratory Syndrome Virus
title_full_unstemmed Research Progress on Glycoprotein 5 of Porcine Reproductive and Respiratory Syndrome Virus
title_short Research Progress on Glycoprotein 5 of Porcine Reproductive and Respiratory Syndrome Virus
title_sort research progress on glycoprotein 5 of porcine reproductive and respiratory syndrome virus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000246/
https://www.ncbi.nlm.nih.gov/pubmed/36899670
http://dx.doi.org/10.3390/ani13050813
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