Cargando…

Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India

OBJECTIVE: Chronic obstructive airway disease (COPD) is characterized by airflow limitation due to airway and/or alveolar abnormalities with significant extra‐pulmonary manifestations. Bone health impairment is an extra‐pulmonary complication of COPD which is less well studied in India. Moreover, it...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeeyavudeen, Mohammad Sadiq, Hansdek, Samuel George, Thomas, Nihal, Balamugesh, Thangakunam, Gowri, Mahasampath, Paul, Thomas V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000280/
https://www.ncbi.nlm.nih.gov/pubmed/36911094
http://dx.doi.org/10.1002/agm2.12239
_version_ 1784903836909961216
author Jeeyavudeen, Mohammad Sadiq
Hansdek, Samuel George
Thomas, Nihal
Balamugesh, Thangakunam
Gowri, Mahasampath
Paul, Thomas V.
author_facet Jeeyavudeen, Mohammad Sadiq
Hansdek, Samuel George
Thomas, Nihal
Balamugesh, Thangakunam
Gowri, Mahasampath
Paul, Thomas V.
author_sort Jeeyavudeen, Mohammad Sadiq
collection PubMed
description OBJECTIVE: Chronic obstructive airway disease (COPD) is characterized by airflow limitation due to airway and/or alveolar abnormalities with significant extra‐pulmonary manifestations. Bone health impairment is an extra‐pulmonary complication of COPD which is less well studied in India. Moreover, it can contribute to significant morbidity and mortality. Hence, we aim to estimate the prevalence of osteoporosis and metabolic parameters of adverse bone health in patients with COPD. METHODS: In this case control study, male subjects aged 40–70 years with COPD attending the respiratory outpatient clinic in a tertiary care hospital were recruited over a period of 2 years and the control population were derived from the historical cohort who were apparently healthy with no obvious diseases. Metabolic parameters of bone health measured from fasting blood samples were calcium, albumin, alkaline phosphatase, phosphorous, parathormone, creatinine, 25‐hydroxy vitamin D, and testosterone. Bone mineral density (BMD) was estimated using DXA scan and the World Health Organization (WHO) criteria was used to categorize into osteoporosis, osteopenia, and normal BMD based on the T‐score at femoral neck, lumbar spine and distal forearm. Pulmonary function tests and 6 minute walk test were performed if they had not been done in the previous 3 months. The associations of COPD with osteoporosis were analyzed using linear regression analysis and effect size are presented as beta with 95% confidence interval. RESULTS: Of the 67 participants with COPD enrolled in the study, osteoporosis was present in 61% (41/67) and osteopenia in an additional 33% (22/67) of the cases, which was higher when compared to the control population (osteoporosis 20% [50/252] and osteopenia 58% [146/252]). In regression modeling, there was a trend toward adverse bone health with advanced age, low body mass index, low forced expiratory volume in 1 second and testosterone deficiency in COPD. CONCLUSION: Individuals with COPD have a substantially higher prevalence of osteoporosis and osteopenia, up to almost twice that of the general population, with a significant number demonstrating at least one parameter of adverse metabolic bone health on assessment. Hence, bone health assessment should be a part of comprehensive COPD care to prevent adverse consequences due to poor bone health.
format Online
Article
Text
id pubmed-10000280
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-100002802023-03-11 Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India Jeeyavudeen, Mohammad Sadiq Hansdek, Samuel George Thomas, Nihal Balamugesh, Thangakunam Gowri, Mahasampath Paul, Thomas V. Aging Med (Milton) Original Articles OBJECTIVE: Chronic obstructive airway disease (COPD) is characterized by airflow limitation due to airway and/or alveolar abnormalities with significant extra‐pulmonary manifestations. Bone health impairment is an extra‐pulmonary complication of COPD which is less well studied in India. Moreover, it can contribute to significant morbidity and mortality. Hence, we aim to estimate the prevalence of osteoporosis and metabolic parameters of adverse bone health in patients with COPD. METHODS: In this case control study, male subjects aged 40–70 years with COPD attending the respiratory outpatient clinic in a tertiary care hospital were recruited over a period of 2 years and the control population were derived from the historical cohort who were apparently healthy with no obvious diseases. Metabolic parameters of bone health measured from fasting blood samples were calcium, albumin, alkaline phosphatase, phosphorous, parathormone, creatinine, 25‐hydroxy vitamin D, and testosterone. Bone mineral density (BMD) was estimated using DXA scan and the World Health Organization (WHO) criteria was used to categorize into osteoporosis, osteopenia, and normal BMD based on the T‐score at femoral neck, lumbar spine and distal forearm. Pulmonary function tests and 6 minute walk test were performed if they had not been done in the previous 3 months. The associations of COPD with osteoporosis were analyzed using linear regression analysis and effect size are presented as beta with 95% confidence interval. RESULTS: Of the 67 participants with COPD enrolled in the study, osteoporosis was present in 61% (41/67) and osteopenia in an additional 33% (22/67) of the cases, which was higher when compared to the control population (osteoporosis 20% [50/252] and osteopenia 58% [146/252]). In regression modeling, there was a trend toward adverse bone health with advanced age, low body mass index, low forced expiratory volume in 1 second and testosterone deficiency in COPD. CONCLUSION: Individuals with COPD have a substantially higher prevalence of osteoporosis and osteopenia, up to almost twice that of the general population, with a significant number demonstrating at least one parameter of adverse metabolic bone health on assessment. Hence, bone health assessment should be a part of comprehensive COPD care to prevent adverse consequences due to poor bone health. John Wiley and Sons Inc. 2023-01-12 /pmc/articles/PMC10000280/ /pubmed/36911094 http://dx.doi.org/10.1002/agm2.12239 Text en © 2023 The Authors. Aging Medicine published by Beijing Hospital and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Jeeyavudeen, Mohammad Sadiq
Hansdek, Samuel George
Thomas, Nihal
Balamugesh, Thangakunam
Gowri, Mahasampath
Paul, Thomas V.
Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India
title Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India
title_full Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India
title_fullStr Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India
title_full_unstemmed Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India
title_short Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India
title_sort bone health in ambulatory male patients with chronic obstructive airway disease – a case control study from india
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000280/
https://www.ncbi.nlm.nih.gov/pubmed/36911094
http://dx.doi.org/10.1002/agm2.12239
work_keys_str_mv AT jeeyavudeenmohammadsadiq bonehealthinambulatorymalepatientswithchronicobstructiveairwaydiseaseacasecontrolstudyfromindia
AT hansdeksamuelgeorge bonehealthinambulatorymalepatientswithchronicobstructiveairwaydiseaseacasecontrolstudyfromindia
AT thomasnihal bonehealthinambulatorymalepatientswithchronicobstructiveairwaydiseaseacasecontrolstudyfromindia
AT balamugeshthangakunam bonehealthinambulatorymalepatientswithchronicobstructiveairwaydiseaseacasecontrolstudyfromindia
AT gowrimahasampath bonehealthinambulatorymalepatientswithchronicobstructiveairwaydiseaseacasecontrolstudyfromindia
AT paulthomasv bonehealthinambulatorymalepatientswithchronicobstructiveairwaydiseaseacasecontrolstudyfromindia