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Role of RUNX3 in Restriction Point Regulation

A cell cycle is a series of events that takes place in a cell as it grows and divides. At the G(1) phase of cell cycle, cells monitor their cumulative exposure to specific signals and make the critical decision to pass through the restriction (R)-point. The R-point decision-making machinery is funda...

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Autores principales: Lee, Jung-Won, Lee, You-Soub, Kim, Min-Kyu, Chi, Xin-Zi, Kim, Dohun, Bae, Suk-Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000377/
https://www.ncbi.nlm.nih.gov/pubmed/36899846
http://dx.doi.org/10.3390/cells12050708
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author Lee, Jung-Won
Lee, You-Soub
Kim, Min-Kyu
Chi, Xin-Zi
Kim, Dohun
Bae, Suk-Chul
author_facet Lee, Jung-Won
Lee, You-Soub
Kim, Min-Kyu
Chi, Xin-Zi
Kim, Dohun
Bae, Suk-Chul
author_sort Lee, Jung-Won
collection PubMed
description A cell cycle is a series of events that takes place in a cell as it grows and divides. At the G(1) phase of cell cycle, cells monitor their cumulative exposure to specific signals and make the critical decision to pass through the restriction (R)-point. The R-point decision-making machinery is fundamental to normal differentiation, apoptosis, and G(1)–S transition. Deregulation of this machinery is markedly associated with tumorigenesis. Therefore, identification of the molecular mechanisms that govern the R-point decision is one of the fundamental issues in tumor biology. RUNX3 is one of the genes frequently inactivated in tumors by epigenetic alterations. In particular, RUNX3 is downregulated in most K-RAS-activated human and mouse lung adenocarcinomas (ADCs). Targeted inactivation of Runx3 in the mouse lung induces adenomas (ADs), and markedly shortens the latency of ADC formation induced by oncogenic K-Ras. RUNX3 participates in the transient formation of R-point-associated activator (RPA-RX3-AC) complexes, which measure the duration of RAS signals and thereby protect cells against oncogenic RAS. This review focuses on the molecular mechanism by which the R-point participates in oncogenic surveillance.
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spelling pubmed-100003772023-03-11 Role of RUNX3 in Restriction Point Regulation Lee, Jung-Won Lee, You-Soub Kim, Min-Kyu Chi, Xin-Zi Kim, Dohun Bae, Suk-Chul Cells Review A cell cycle is a series of events that takes place in a cell as it grows and divides. At the G(1) phase of cell cycle, cells monitor their cumulative exposure to specific signals and make the critical decision to pass through the restriction (R)-point. The R-point decision-making machinery is fundamental to normal differentiation, apoptosis, and G(1)–S transition. Deregulation of this machinery is markedly associated with tumorigenesis. Therefore, identification of the molecular mechanisms that govern the R-point decision is one of the fundamental issues in tumor biology. RUNX3 is one of the genes frequently inactivated in tumors by epigenetic alterations. In particular, RUNX3 is downregulated in most K-RAS-activated human and mouse lung adenocarcinomas (ADCs). Targeted inactivation of Runx3 in the mouse lung induces adenomas (ADs), and markedly shortens the latency of ADC formation induced by oncogenic K-Ras. RUNX3 participates in the transient formation of R-point-associated activator (RPA-RX3-AC) complexes, which measure the duration of RAS signals and thereby protect cells against oncogenic RAS. This review focuses on the molecular mechanism by which the R-point participates in oncogenic surveillance. MDPI 2023-02-23 /pmc/articles/PMC10000377/ /pubmed/36899846 http://dx.doi.org/10.3390/cells12050708 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee, Jung-Won
Lee, You-Soub
Kim, Min-Kyu
Chi, Xin-Zi
Kim, Dohun
Bae, Suk-Chul
Role of RUNX3 in Restriction Point Regulation
title Role of RUNX3 in Restriction Point Regulation
title_full Role of RUNX3 in Restriction Point Regulation
title_fullStr Role of RUNX3 in Restriction Point Regulation
title_full_unstemmed Role of RUNX3 in Restriction Point Regulation
title_short Role of RUNX3 in Restriction Point Regulation
title_sort role of runx3 in restriction point regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000377/
https://www.ncbi.nlm.nih.gov/pubmed/36899846
http://dx.doi.org/10.3390/cells12050708
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