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[(18)F]FDG PET/CT in the Evaluation of Melanoma Patients Treated with Immunotherapy

Immunotherapy is based on manipulation of the immune system in order to act against tumour cells, with growing evidence especially in melanoma patients. The challenges faced by this new therapeutic tool are (i) finding valid evaluation criteria for response assessment; (ii) knowing and distinguishin...

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Autores principales: Mangas Losada, María, Romero Robles, Leonardo, Mendoza Melero, Alejandro, García Megías, Irene, Villanueva Torres, Amós, Garrastachu Zumarán, Puy, Boulvard Chollet, Xavier, Lopci, Egesta, Ramírez Lasanta, Rafael, Delgado Bolton, Roberto C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000458/
https://www.ncbi.nlm.nih.gov/pubmed/36900122
http://dx.doi.org/10.3390/diagnostics13050978
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author Mangas Losada, María
Romero Robles, Leonardo
Mendoza Melero, Alejandro
García Megías, Irene
Villanueva Torres, Amós
Garrastachu Zumarán, Puy
Boulvard Chollet, Xavier
Lopci, Egesta
Ramírez Lasanta, Rafael
Delgado Bolton, Roberto C.
author_facet Mangas Losada, María
Romero Robles, Leonardo
Mendoza Melero, Alejandro
García Megías, Irene
Villanueva Torres, Amós
Garrastachu Zumarán, Puy
Boulvard Chollet, Xavier
Lopci, Egesta
Ramírez Lasanta, Rafael
Delgado Bolton, Roberto C.
author_sort Mangas Losada, María
collection PubMed
description Immunotherapy is based on manipulation of the immune system in order to act against tumour cells, with growing evidence especially in melanoma patients. The challenges faced by this new therapeutic tool are (i) finding valid evaluation criteria for response assessment; (ii) knowing and distinguishing between “atypical” response patterns; (iii) using PET biomarkers as predictive and response evaluation parameters and (iv) diagnosis and management of immunorelated adverse effects. This review is focused on melanoma patients analysing (a) the role of [(18)F]FDG PET/CT in the mentioned challenges; (b) the evidence of its efficacy. For this purpose, we performed a review of the literature, including original and review articles. In summary, although there are no clearly established or globally accepted criteria, modified response criteria are potentially appropriate for evaluation of immunotherapy benefit. In this context, [(18)F]FDG PET/CT biomarkers appear to be promising parameters in prediction and assessment of response to immunotherapy. Moreover, immunorelated adverse effects are recognized as predictors of early response to immunotherapy and may be associated with better prognosis and clinical benefit.
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spelling pubmed-100004582023-03-11 [(18)F]FDG PET/CT in the Evaluation of Melanoma Patients Treated with Immunotherapy Mangas Losada, María Romero Robles, Leonardo Mendoza Melero, Alejandro García Megías, Irene Villanueva Torres, Amós Garrastachu Zumarán, Puy Boulvard Chollet, Xavier Lopci, Egesta Ramírez Lasanta, Rafael Delgado Bolton, Roberto C. Diagnostics (Basel) Review Immunotherapy is based on manipulation of the immune system in order to act against tumour cells, with growing evidence especially in melanoma patients. The challenges faced by this new therapeutic tool are (i) finding valid evaluation criteria for response assessment; (ii) knowing and distinguishing between “atypical” response patterns; (iii) using PET biomarkers as predictive and response evaluation parameters and (iv) diagnosis and management of immunorelated adverse effects. This review is focused on melanoma patients analysing (a) the role of [(18)F]FDG PET/CT in the mentioned challenges; (b) the evidence of its efficacy. For this purpose, we performed a review of the literature, including original and review articles. In summary, although there are no clearly established or globally accepted criteria, modified response criteria are potentially appropriate for evaluation of immunotherapy benefit. In this context, [(18)F]FDG PET/CT biomarkers appear to be promising parameters in prediction and assessment of response to immunotherapy. Moreover, immunorelated adverse effects are recognized as predictors of early response to immunotherapy and may be associated with better prognosis and clinical benefit. MDPI 2023-03-04 /pmc/articles/PMC10000458/ /pubmed/36900122 http://dx.doi.org/10.3390/diagnostics13050978 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mangas Losada, María
Romero Robles, Leonardo
Mendoza Melero, Alejandro
García Megías, Irene
Villanueva Torres, Amós
Garrastachu Zumarán, Puy
Boulvard Chollet, Xavier
Lopci, Egesta
Ramírez Lasanta, Rafael
Delgado Bolton, Roberto C.
[(18)F]FDG PET/CT in the Evaluation of Melanoma Patients Treated with Immunotherapy
title [(18)F]FDG PET/CT in the Evaluation of Melanoma Patients Treated with Immunotherapy
title_full [(18)F]FDG PET/CT in the Evaluation of Melanoma Patients Treated with Immunotherapy
title_fullStr [(18)F]FDG PET/CT in the Evaluation of Melanoma Patients Treated with Immunotherapy
title_full_unstemmed [(18)F]FDG PET/CT in the Evaluation of Melanoma Patients Treated with Immunotherapy
title_short [(18)F]FDG PET/CT in the Evaluation of Melanoma Patients Treated with Immunotherapy
title_sort [(18)f]fdg pet/ct in the evaluation of melanoma patients treated with immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000458/
https://www.ncbi.nlm.nih.gov/pubmed/36900122
http://dx.doi.org/10.3390/diagnostics13050978
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