Management and Oncologic Outcomes of Close and Positive Margins after Transoral CO(2) Laser Microsurgery for Early Glottic Carcinoma

SIMPLE SUMMARY: The management of close and/or positive margins after transoral CO(2) laser microsurgery (CO(2) TOLMS) is still an ongoing matter of discussion. Different options have been suggested on the basis of the number of the involved margins (single vs. multiple) and site (deep vs. superficial): strict follow-up, revision surgery or radiotherapy. However, precise indications about additional treatment and its effective impact on local control and survival rates are still lacking. The authors reviewed 351 patients with early glottic cancer treated using CO(2) TOLMS with the aim of analyzing the impact of margin status on local control and survival, and discussing the therapeutic options in cases of close and positive margins. ABSTRACT: Background: The present study analyzed the impact of margin status on local control and survival, and the management of close/positive margins after transoral CO(2) laser microsurgery for early glottic carcinoma. Methods: 351 patients (328 males, 23 females, mean age 65.6 years) underwent surgery. We identified the following margin statuses: negative, close superficial (CS), close deep (CD), positive single superficial (SS), positive multiple superficial (MS), and positive deep (DEEP). Results: A total of 286 patients (81.5%) had negative margins, 23 (6.5%) had close margins (8 CS, 15 CD) and 42 (12%) had positive margins (16 SS, 9 MS, 17 DEEP). Among the 65 patients with close/positive margins, 44 patients underwent enlargement, 6 radiotherapy and 15 follow-up. Twenty-two patients (6.3%) recurred. Patients with DEEP or CD margins showed a higher risk of recurrence (hazard ratios of 2.863 and 2.537, respectively), compared to patients with negative margins. Local control with laser alone, overall laryngeal preservation and disease-specific survival decreased significantly in patients with DEEP margins (57.5%, 86.9% and 92.9%, p < 0.05). Conclusions: Patients with CS or SS margins could be safely submitted to follow-up. In the case of CD and MS margins, any additional treatment should be discussed with the patient. In the case of DEEP margin, additional treatment is always recommended.