Cargando…

CFTR Inhibitors Display In Vitro Antiviral Activity against SARS-CoV-2

Several reports have indicated that SARS-CoV-2 infection displays unexpected mild clinical manifestations in people with cystic fibrosis (pwCF), suggesting that CFTR expression and function may be involved in the SARS-CoV-2 life cycle. To evaluate the possible association of CFTR activity with SARS-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lagni, Anna, Lotti, Virginia, Diani, Erica, Rossini, Giada, Concia, Ercole, Sorio, Claudio, Gibellini, Davide
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000629/ https://www.ncbi.nlm.nih.gov/pubmed/36899912 http://dx.doi.org/10.3390/cells12050776

Ejemplares similares

CFTR Modulation Reduces SARS-CoV-2 Infection in Human Bronchial Epithelial Cells
por: Lotti, Virginia, et al.
Publicado: (2022)

Crosslink between SARS-CoV-2 replication and cystic fibrosis hallmarks
por: Lotti, Virginia, et al.
Publicado: (2023)

Vector-Transmitted Flaviviruses: An Antiviral Molecules Overview
por: Diani, Erica, et al.
Publicado: (2023)

WS05.04 SARS-CoV-2 infection is reduced in both immortalised and primary CFTR-modulated human bronchial epithelial cells
por: Lotti, V., et al.
Publicado: (2022)

Ultrastructural Characterization of Human Bronchial Epithelial Cells during SARS-CoV-2 Infection: Morphological Comparison of Wild-Type and CFTR-Modified Cells
por: Merigo, Flavia, et al.
Publicado: (2022)

Evaluation of saliva and nasopharyngeal swab sampling for genomic detection of SARS-CoV-2 in children accessing a pediatric emergency department during the second pandemic wave
por: Diani, Erica, et al.
Publicado: (2023)

Cross-Immunization Against Respiratory Coronaviruses May Protect Children From SARS-CoV2: More Than a Simple Hypothesis?
por: Piccaluga, Pier Paolo, et al.
Publicado: (2021)

COVID-19 Vaccine: Between Myth and Truth
por: Piccaluga, Pier Paolo, et al.
Publicado: (2022)

439 Cystic fibrosis transmembrane conductance regulator impairment strongly decreases SARS-CoV-2 replication in human bronchial epithelial cells
por: Sorio, C., et al.
Publicado: (2022)

Assessment of SARS-CoV-2 IgG and IgM antibody detection with a lateral flow immunoassay test
por: Diani, Erica, et al.
Publicado: (2021)

Detection of SARS-CoV-2 Δ426 ORF8 Deletion Mutant Cluster in NGS Screening
por: Cecchetto, Riccardo, et al.
Publicado: (2023)

Post-Vaccination SARS-CoV-2 Infections among Health Workers at the University Hospital of Verona, Italy: A Retrospective Cohort Survey
por: Porru, Stefano, et al.
Publicado: (2022)

CFTR Modulators Rescue the Activity of CFTR in Colonoids Expressing the Complex Allele p.[R74W;V201M;D1270N]/dele22_24
por: Kleinfelder, Karina, et al.
Publicado: (2023)

Duplex real-time polymerase chain reaction assay for the detection of human KIPyV and WUPyV in nasopharyngeal aspirate pediatric samples
por: Ligozzi, Marco, et al.
Publicado: (2018)

In vivo monitoring of lung inflammation in CFTR-deficient mice
por: Stellari, Fabio, et al.
Publicado: (2016)

SARS-CoV-2 and Its Variants in Thrice-Infected Health Workers: A Case Series from an Italian University Hospital
por: Monaco, Maria Grazia Lourdes, et al.
Publicado: (2022)

CFTR displays voltage dependence and two gating modes during stimulation
Publicado: (1994)

Epimedium koreanum Nakai Displays Broad Spectrum of Antiviral Activity in Vitro and in Vivo by Inducing Cellular Antiviral State
por: Cho, Won-Kyung, et al.
Publicado: (2015)

Airway Epithelial Inflammation In Vitro Augments the Rescue of Mutant CFTR by Current CFTR Modulator Therapies
por: Gentzsch, Martina, et al.
Publicado: (2021)

SARS-CoV-2-Associated ssRNAs Activate Human Neutrophils in a TLR8-Dependent Fashion
por: Gardiman, Elisa, et al.
Publicado: (2022)

Structure-based discovery of CFTR potentiators and inhibitors
por: Liu, Fangyu, et al.
Publicado: (2023)

Defective CFTR Expression and Function Are Detectable in Blood Monocytes: Development of a New Blood Test for Cystic Fibrosis
por: Sorio, Claudio, et al.
Publicado: (2011)

Discovery of Antivirals Using Phage Display
por: Sokullu, Esen, et al.
Publicado: (2021)

Revisiting CFTR inhibition: a comparative study of CFTR(inh)-172 and GlyH-101 inhibitors
por: Melis, N, et al.
Publicado: (2014)

CFTR mutations altering CFTR fragmentation
por: Tosoni, Kendra, et al.
Publicado: (2012)

Identification of Potential Leukocyte Biomarkers Related to Drug Recovery of CFTR: Clinical Applications in Cystic Fibrosis
por: Pedrazzi, Marco, et al.
Publicado: (2021)

Interferon gamma inducible protein 16 (IFI16) expression is reduced in mantle cell lymphoma
por: Piccaluga, Pier Paolo, et al.
Publicado: (2019)

Assays of CFTR Function In Vitro, Ex Vivo and In Vivo
por: Ramalho, Anabela S., et al.
Publicado: (2022)

Theratyping of the Rare CFTR Variants E193K and R334W in Rectal Organoid-Derived Epithelial Monolayers
por: Ciciriello, Fabiana, et al.
Publicado: (2022)

Theratyping of the Rare CFTR Genotype A559T in Rectal Organoids and Nasal Cells Reveals a Relevant Response to Elexacaftor (VX-445) and Tezacaftor (VX-661) Combination
por: Kleinfelder, Karina, et al.
Publicado: (2023)

Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2
por: Chuong, Christina, et al.
Publicado: (2021)

In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells
por: Kleinfelder, Karina, et al.
Publicado: (2023)

Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro
por: Zhang, Leike, et al.
Publicado: (2020)

Piceatannol as an Antiviral Inhibitor of PRV Infection In Vitro and In Vivo
por: Wang, Zhiying, et al.
Publicado: (2023)

A cysteine protease inhibitor GC376 displays potent antiviral activity against coxsackievirus infection
por: Chen, Yongkang, et al.
Publicado: (2023)

M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures
por: Musumeci, Giuseppina, et al.
Publicado: (2017)

Pharmacological Responses of the G542X-CFTR to CFTR Modulators
por: Fang, Xinxiu, et al.
Publicado: (2022)

Cost of care and antibiotic prescribing attitudes for community-acquired complicated intra-abdominal infections in Italy: a retrospective study
por: Dalfino, Lidia, et al.
Publicado: (2014)

CFTR Gating I: Characterization of the ATP-dependent Gating of a Phosphorylation-independent CFTR Channel (ΔR-CFTR)
por: Bompadre, Silvia G., et al.
Publicado: (2005)

Structural models of CFTR–AMPK and CFTR–PKA interactions: R-domain flexibility is a key factor in CFTR regulation
por: Siwiak, Marian, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_7q5tiu6kdgogabn4923kc830g3