An Updated Review of Hypertrophic Scarring

Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with excessive deposition of extracellular matrix and connective tissue at the site of injury. In this review article, we provide an overview of normal (acute) wound healing phases (hemostasis, inflammation, prolifer...

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Detalles Bibliográficos
Autores principales: Mony, Manjula P., Harmon, Kelly A., Hess, Ryan, Dorafshar, Amir H., Shafikhani, Sasha H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000648/
https://www.ncbi.nlm.nih.gov/pubmed/36899815
http://dx.doi.org/10.3390/cells12050678
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author Mony, Manjula P.
Harmon, Kelly A.
Hess, Ryan
Dorafshar, Amir H.
Shafikhani, Sasha H.
author_facet Mony, Manjula P.
Harmon, Kelly A.
Hess, Ryan
Dorafshar, Amir H.
Shafikhani, Sasha H.
author_sort Mony, Manjula P.
collection PubMed
description Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with excessive deposition of extracellular matrix and connective tissue at the site of injury. In this review article, we provide an overview of normal (acute) wound healing phases (hemostasis, inflammation, proliferation, and remodeling). We next discuss the dysregulated and/or impaired mechanisms in wound healing phases that are associated with HTS development. We next discuss the animal models of HTS and their limitations, and review the current and emerging treatments of HTS.
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spelling pubmed-100006482023-03-11 An Updated Review of Hypertrophic Scarring Mony, Manjula P. Harmon, Kelly A. Hess, Ryan Dorafshar, Amir H. Shafikhani, Sasha H. Cells Review Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with excessive deposition of extracellular matrix and connective tissue at the site of injury. In this review article, we provide an overview of normal (acute) wound healing phases (hemostasis, inflammation, proliferation, and remodeling). We next discuss the dysregulated and/or impaired mechanisms in wound healing phases that are associated with HTS development. We next discuss the animal models of HTS and their limitations, and review the current and emerging treatments of HTS. MDPI 2023-02-21 /pmc/articles/PMC10000648/ /pubmed/36899815 http://dx.doi.org/10.3390/cells12050678 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mony, Manjula P.
Harmon, Kelly A.
Hess, Ryan
Dorafshar, Amir H.
Shafikhani, Sasha H.
An Updated Review of Hypertrophic Scarring
title An Updated Review of Hypertrophic Scarring
title_full An Updated Review of Hypertrophic Scarring
title_fullStr An Updated Review of Hypertrophic Scarring
title_full_unstemmed An Updated Review of Hypertrophic Scarring
title_short An Updated Review of Hypertrophic Scarring
title_sort updated review of hypertrophic scarring
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000648/
https://www.ncbi.nlm.nih.gov/pubmed/36899815
http://dx.doi.org/10.3390/cells12050678
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