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Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients
Vitamin D deficiency is one of the most common medical conditions, with approximately one billion people having low vitamin D levels. Vitamin D is associated with a pleiotropic effect (immunomodulatory, anti-inflammatory and antiviral), which can be essential for a better immune response. The aim of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000859/ https://www.ncbi.nlm.nih.gov/pubmed/36900141 http://dx.doi.org/10.3390/diagnostics13050998 |
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author | Bucurica, Sandica Prodan, Ioana Pavalean, Mihaela Taubner, Corina Bucurica, Ana Socol, Calin Calin, Roxana Ionita-Radu, Florentina Jinga, Mariana |
author_facet | Bucurica, Sandica Prodan, Ioana Pavalean, Mihaela Taubner, Corina Bucurica, Ana Socol, Calin Calin, Roxana Ionita-Radu, Florentina Jinga, Mariana |
author_sort | Bucurica, Sandica |
collection | PubMed |
description | Vitamin D deficiency is one of the most common medical conditions, with approximately one billion people having low vitamin D levels. Vitamin D is associated with a pleiotropic effect (immunomodulatory, anti-inflammatory and antiviral), which can be essential for a better immune response. The aim of this research was to evaluate the prevalence of vitamin D deficiency/insufficiency in hospitalized patients focusing on demographic parameters as well as assessing the possibility of its associations with different comorbidities. Of 11,182 Romanian patients evaluated in the study over 2 years, 28.83% had vitamin D deficiency, 32.11% insufficiency and 39.05% had optimal vitamin D levels. The vitamin D deficiency was associated with cardiovascular disorders, malignancies, dysmetabolic disorders and SARS-CoV2 infection, older age and the male sex. Vitamin D deficiency was prevalent and showed pathology association, while insufficiency of vitamin D (20–30 ng/mL) had lower statistical relevance and represents a grey zone in vitamin D status. Guidelines and recommendations are necessary for homogeneity of the monitoring and management of inadequately vitamin D status in the risk categories. |
format | Online Article Text |
id | pubmed-10000859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100008592023-03-11 Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients Bucurica, Sandica Prodan, Ioana Pavalean, Mihaela Taubner, Corina Bucurica, Ana Socol, Calin Calin, Roxana Ionita-Radu, Florentina Jinga, Mariana Diagnostics (Basel) Article Vitamin D deficiency is one of the most common medical conditions, with approximately one billion people having low vitamin D levels. Vitamin D is associated with a pleiotropic effect (immunomodulatory, anti-inflammatory and antiviral), which can be essential for a better immune response. The aim of this research was to evaluate the prevalence of vitamin D deficiency/insufficiency in hospitalized patients focusing on demographic parameters as well as assessing the possibility of its associations with different comorbidities. Of 11,182 Romanian patients evaluated in the study over 2 years, 28.83% had vitamin D deficiency, 32.11% insufficiency and 39.05% had optimal vitamin D levels. The vitamin D deficiency was associated with cardiovascular disorders, malignancies, dysmetabolic disorders and SARS-CoV2 infection, older age and the male sex. Vitamin D deficiency was prevalent and showed pathology association, while insufficiency of vitamin D (20–30 ng/mL) had lower statistical relevance and represents a grey zone in vitamin D status. Guidelines and recommendations are necessary for homogeneity of the monitoring and management of inadequately vitamin D status in the risk categories. MDPI 2023-03-06 /pmc/articles/PMC10000859/ /pubmed/36900141 http://dx.doi.org/10.3390/diagnostics13050998 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bucurica, Sandica Prodan, Ioana Pavalean, Mihaela Taubner, Corina Bucurica, Ana Socol, Calin Calin, Roxana Ionita-Radu, Florentina Jinga, Mariana Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients |
title | Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients |
title_full | Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients |
title_fullStr | Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients |
title_full_unstemmed | Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients |
title_short | Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients |
title_sort | association of vitamin d deficiency and insufficiency with pathology in hospitalized patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000859/ https://www.ncbi.nlm.nih.gov/pubmed/36900141 http://dx.doi.org/10.3390/diagnostics13050998 |
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