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Endometriosis and cardiovascular disease: a population-based cohort study

BACKGROUND: Endometriosis, a prevalent condition among females of reproductive age, may be associated with increased risk of cardiovascular disease (CVD) through chronic inflammation and early menopause. The objective of this study was to estimate the association between endometriosis and subsequent...

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Autores principales: Blom, Jessica N., Velez, Maria P., McClintock, Chad, Shellenberger, Jonas, Pudwell, Jessica, Brogly, Susan B., Bougie, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: CMA Impact Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000901/
https://www.ncbi.nlm.nih.gov/pubmed/36882211
http://dx.doi.org/10.9778/cmajo.20220144
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author Blom, Jessica N.
Velez, Maria P.
McClintock, Chad
Shellenberger, Jonas
Pudwell, Jessica
Brogly, Susan B.
Bougie, Olga
author_facet Blom, Jessica N.
Velez, Maria P.
McClintock, Chad
Shellenberger, Jonas
Pudwell, Jessica
Brogly, Susan B.
Bougie, Olga
author_sort Blom, Jessica N.
collection PubMed
description BACKGROUND: Endometriosis, a prevalent condition among females of reproductive age, may be associated with increased risk of cardiovascular disease (CVD) through chronic inflammation and early menopause. The objective of this study was to estimate the association between endometriosis and subsequent risk of CVD. METHODS: We conducted a population-based cohort study using administrative health data from Ontario residents from 1993 to 2015. We compared the incidence of CVD and cardiovascular health outcomes between females with endometriosis and 2 age-matched females without endometriosis. The primary outcome was hospital admission for CVD. Secondary outcomes included in-hospital CVD events of interest and emergency department visits for CVD. We used Cox proportional hazards models to estimate adjusted hazard ratios (HRs) between endometriosis and CVD events. RESULTS: We identified 166 835 eligible patients with endometriosis and matched 333 706 patients without endometriosis. The mean age of those with endometriosis was 36.4 years. Patients with endometriosis had a higher incidence of hospital admission for CVD (195 admissions/100 000 person-years) compared with those without endometriosis (163 admissions/100 000 person-years). Similarly, the incidence of secondary CVD events was slightly higher among patients with endometriosis (292 cases/100 000 person-years) than among those without endometriosis (224 cases/100 000 person-years). Females with endometriosis had an increased risk of hospital admission (adjusted HR 1.14, 95% confidence interval [CI] 1.10–1.19) and secondary CVD events (adjusted HR 1.26, 95% CI 1.23–1.30). INTERPRETATION: In this large, population-based study, endometriosis was associated with a small increased risk of CVD events. Future studies need to investigate potential etiological mechanisms and strategies to decrease long-term CVD risk in patients with endometriosis.
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spelling pubmed-100009012023-03-11 Endometriosis and cardiovascular disease: a population-based cohort study Blom, Jessica N. Velez, Maria P. McClintock, Chad Shellenberger, Jonas Pudwell, Jessica Brogly, Susan B. Bougie, Olga CMAJ Open Research BACKGROUND: Endometriosis, a prevalent condition among females of reproductive age, may be associated with increased risk of cardiovascular disease (CVD) through chronic inflammation and early menopause. The objective of this study was to estimate the association between endometriosis and subsequent risk of CVD. METHODS: We conducted a population-based cohort study using administrative health data from Ontario residents from 1993 to 2015. We compared the incidence of CVD and cardiovascular health outcomes between females with endometriosis and 2 age-matched females without endometriosis. The primary outcome was hospital admission for CVD. Secondary outcomes included in-hospital CVD events of interest and emergency department visits for CVD. We used Cox proportional hazards models to estimate adjusted hazard ratios (HRs) between endometriosis and CVD events. RESULTS: We identified 166 835 eligible patients with endometriosis and matched 333 706 patients without endometriosis. The mean age of those with endometriosis was 36.4 years. Patients with endometriosis had a higher incidence of hospital admission for CVD (195 admissions/100 000 person-years) compared with those without endometriosis (163 admissions/100 000 person-years). Similarly, the incidence of secondary CVD events was slightly higher among patients with endometriosis (292 cases/100 000 person-years) than among those without endometriosis (224 cases/100 000 person-years). Females with endometriosis had an increased risk of hospital admission (adjusted HR 1.14, 95% confidence interval [CI] 1.10–1.19) and secondary CVD events (adjusted HR 1.26, 95% CI 1.23–1.30). INTERPRETATION: In this large, population-based study, endometriosis was associated with a small increased risk of CVD events. Future studies need to investigate potential etiological mechanisms and strategies to decrease long-term CVD risk in patients with endometriosis. CMA Impact Inc. 2023-03-07 /pmc/articles/PMC10000901/ /pubmed/36882211 http://dx.doi.org/10.9778/cmajo.20220144 Text en © 2023 CMA Impact Inc. or its licensors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that the original publication is properly cited, the use is noncommercial (i.e., research or educational use), and no modifications or adaptations are made. See: https://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Research
Blom, Jessica N.
Velez, Maria P.
McClintock, Chad
Shellenberger, Jonas
Pudwell, Jessica
Brogly, Susan B.
Bougie, Olga
Endometriosis and cardiovascular disease: a population-based cohort study
title Endometriosis and cardiovascular disease: a population-based cohort study
title_full Endometriosis and cardiovascular disease: a population-based cohort study
title_fullStr Endometriosis and cardiovascular disease: a population-based cohort study
title_full_unstemmed Endometriosis and cardiovascular disease: a population-based cohort study
title_short Endometriosis and cardiovascular disease: a population-based cohort study
title_sort endometriosis and cardiovascular disease: a population-based cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000901/
https://www.ncbi.nlm.nih.gov/pubmed/36882211
http://dx.doi.org/10.9778/cmajo.20220144
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