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The Characteristics of Sentinel Lymph Node Biopsy in Cutaneous Melanoma and the Particularities for Elderly Patients—Experience of a Single Clinic

Background: Melanoma is a malignant tumor that determines approximately 80% of deaths as skin cancer-related. The sentinel lymph node (SLN) represents the first filter of tumor cells toward systemic dissemination. The primary objective was to outline the surgical specifics of the sentinel lymph node...

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Autores principales: Bobircă, Florin, Tebeică, Tiberiu, Pumnea, Adela, Dumitrescu, Dan, Alexandru, Cristina, Banciu, Laura, Popa, Ionela Loredana, Bobircă, Anca, Leventer, Mihaela, Pătrașcu, Traian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001011/
https://www.ncbi.nlm.nih.gov/pubmed/36900069
http://dx.doi.org/10.3390/diagnostics13050926
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author Bobircă, Florin
Tebeică, Tiberiu
Pumnea, Adela
Dumitrescu, Dan
Alexandru, Cristina
Banciu, Laura
Popa, Ionela Loredana
Bobircă, Anca
Leventer, Mihaela
Pătrașcu, Traian
author_facet Bobircă, Florin
Tebeică, Tiberiu
Pumnea, Adela
Dumitrescu, Dan
Alexandru, Cristina
Banciu, Laura
Popa, Ionela Loredana
Bobircă, Anca
Leventer, Mihaela
Pătrașcu, Traian
author_sort Bobircă, Florin
collection PubMed
description Background: Melanoma is a malignant tumor that determines approximately 80% of deaths as skin cancer-related. The sentinel lymph node (SLN) represents the first filter of tumor cells toward systemic dissemination. The primary objective was to outline the surgical specifics of the sentinel lymph node biopsy (SLNB) technique, correlate the location of the lymph node with the radiotracer load, and identify the characteristics of older patients. Methods: In this prospective study, 122 cases of malignant melanoma needing SLNB technique were included, between June 2019 and November 2022, resulting in 162 lymph nodes removed. Results: Patients’ mean age was 54.3 ± 14.4 years old, the prevalence of 70 years and older being 20.5%. The rate of positive SLN was 24.6%, with a single drainage in 68.9% of cases. The frequency of seroma was 14.8%, while reintervention 1.6%. The inguinal nodes had the highest preoperative radiotracer load (p = 0.015). Patients 70 years old or older had significantly more advanced-stage melanoma (68.0% vs. 45.4%, p = 0.044, OR = 2.56) and a higher rate of positive SLN (40.0% vs. 20.6%, p = 0.045,OR = 2.57). Melanoma of the head and neck was more common among older individuals (32.0% vs. 9.3%, p = 0.007,OR = 4.60). Conclusions: The SLNB has a low rate of surgical complications and the positivity of SLN is not related to radiotracer load. Elderly patients are at risk for head and neck melanoma, have more advanced stages, a higher SLN positivity, and a greater rate of surgical complications.
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spelling pubmed-100010112023-03-11 The Characteristics of Sentinel Lymph Node Biopsy in Cutaneous Melanoma and the Particularities for Elderly Patients—Experience of a Single Clinic Bobircă, Florin Tebeică, Tiberiu Pumnea, Adela Dumitrescu, Dan Alexandru, Cristina Banciu, Laura Popa, Ionela Loredana Bobircă, Anca Leventer, Mihaela Pătrașcu, Traian Diagnostics (Basel) Article Background: Melanoma is a malignant tumor that determines approximately 80% of deaths as skin cancer-related. The sentinel lymph node (SLN) represents the first filter of tumor cells toward systemic dissemination. The primary objective was to outline the surgical specifics of the sentinel lymph node biopsy (SLNB) technique, correlate the location of the lymph node with the radiotracer load, and identify the characteristics of older patients. Methods: In this prospective study, 122 cases of malignant melanoma needing SLNB technique were included, between June 2019 and November 2022, resulting in 162 lymph nodes removed. Results: Patients’ mean age was 54.3 ± 14.4 years old, the prevalence of 70 years and older being 20.5%. The rate of positive SLN was 24.6%, with a single drainage in 68.9% of cases. The frequency of seroma was 14.8%, while reintervention 1.6%. The inguinal nodes had the highest preoperative radiotracer load (p = 0.015). Patients 70 years old or older had significantly more advanced-stage melanoma (68.0% vs. 45.4%, p = 0.044, OR = 2.56) and a higher rate of positive SLN (40.0% vs. 20.6%, p = 0.045,OR = 2.57). Melanoma of the head and neck was more common among older individuals (32.0% vs. 9.3%, p = 0.007,OR = 4.60). Conclusions: The SLNB has a low rate of surgical complications and the positivity of SLN is not related to radiotracer load. Elderly patients are at risk for head and neck melanoma, have more advanced stages, a higher SLN positivity, and a greater rate of surgical complications. MDPI 2023-03-01 /pmc/articles/PMC10001011/ /pubmed/36900069 http://dx.doi.org/10.3390/diagnostics13050926 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bobircă, Florin
Tebeică, Tiberiu
Pumnea, Adela
Dumitrescu, Dan
Alexandru, Cristina
Banciu, Laura
Popa, Ionela Loredana
Bobircă, Anca
Leventer, Mihaela
Pătrașcu, Traian
The Characteristics of Sentinel Lymph Node Biopsy in Cutaneous Melanoma and the Particularities for Elderly Patients—Experience of a Single Clinic
title The Characteristics of Sentinel Lymph Node Biopsy in Cutaneous Melanoma and the Particularities for Elderly Patients—Experience of a Single Clinic
title_full The Characteristics of Sentinel Lymph Node Biopsy in Cutaneous Melanoma and the Particularities for Elderly Patients—Experience of a Single Clinic
title_fullStr The Characteristics of Sentinel Lymph Node Biopsy in Cutaneous Melanoma and the Particularities for Elderly Patients—Experience of a Single Clinic
title_full_unstemmed The Characteristics of Sentinel Lymph Node Biopsy in Cutaneous Melanoma and the Particularities for Elderly Patients—Experience of a Single Clinic
title_short The Characteristics of Sentinel Lymph Node Biopsy in Cutaneous Melanoma and the Particularities for Elderly Patients—Experience of a Single Clinic
title_sort characteristics of sentinel lymph node biopsy in cutaneous melanoma and the particularities for elderly patients—experience of a single clinic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001011/
https://www.ncbi.nlm.nih.gov/pubmed/36900069
http://dx.doi.org/10.3390/diagnostics13050926
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