(68)Ga-Pentixafor PET/CT May Fail to Detect Recurrent Multiple Myeloma with Extramedullary Disease

Two patients with a history of multiple myeloma experienced a recurrence of the disease.(18)F-FDG PET/CT revealed prominent extramedullary disease as well as multi-foci in the bone marrow, both with increased FDG uptake. However, on (68)Ga-Pentixafor PET/CT, all the myeloma lesions showed significan...

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Autores principales: Pan, Qingqing, Luo, Yaping, Cao, Xinxin, Li, Jian, Li, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Interesting Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001095/
https://www.ncbi.nlm.nih.gov/pubmed/36900014
http://dx.doi.org/10.3390/diagnostics13050871
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author Pan, Qingqing
Luo, Yaping
Cao, Xinxin
Li, Jian
Li, Fang
author_facet Pan, Qingqing
Luo, Yaping
Cao, Xinxin
Li, Jian
Li, Fang
author_sort Pan, Qingqing
collection PubMed
description Two patients with a history of multiple myeloma experienced a recurrence of the disease.(18)F-FDG PET/CT revealed prominent extramedullary disease as well as multi-foci in the bone marrow, both with increased FDG uptake. However, on (68)Ga-Pentixafor PET/CT, all the myeloma lesions showed significantly lower tracer uptake in comparison with (18)F-FDG PET. This false-negative result of recurrent multiple myeloma with extramedullary disease may be a potential limitation of (68)Ga-Pentixafor in assessing multiple myeloma.
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spelling pubmed-100010952023-03-11 (68)Ga-Pentixafor PET/CT May Fail to Detect Recurrent Multiple Myeloma with Extramedullary Disease Pan, Qingqing Luo, Yaping Cao, Xinxin Li, Jian Li, Fang Diagnostics (Basel) Interesting Images Two patients with a history of multiple myeloma experienced a recurrence of the disease.(18)F-FDG PET/CT revealed prominent extramedullary disease as well as multi-foci in the bone marrow, both with increased FDG uptake. However, on (68)Ga-Pentixafor PET/CT, all the myeloma lesions showed significantly lower tracer uptake in comparison with (18)F-FDG PET. This false-negative result of recurrent multiple myeloma with extramedullary disease may be a potential limitation of (68)Ga-Pentixafor in assessing multiple myeloma. MDPI 2023-02-24 /pmc/articles/PMC10001095/ /pubmed/36900014 http://dx.doi.org/10.3390/diagnostics13050871 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Pan, Qingqing
Luo, Yaping
Cao, Xinxin
Li, Jian
Li, Fang
(68)Ga-Pentixafor PET/CT May Fail to Detect Recurrent Multiple Myeloma with Extramedullary Disease
title (68)Ga-Pentixafor PET/CT May Fail to Detect Recurrent Multiple Myeloma with Extramedullary Disease
title_full (68)Ga-Pentixafor PET/CT May Fail to Detect Recurrent Multiple Myeloma with Extramedullary Disease
title_fullStr (68)Ga-Pentixafor PET/CT May Fail to Detect Recurrent Multiple Myeloma with Extramedullary Disease
title_full_unstemmed (68)Ga-Pentixafor PET/CT May Fail to Detect Recurrent Multiple Myeloma with Extramedullary Disease
title_short (68)Ga-Pentixafor PET/CT May Fail to Detect Recurrent Multiple Myeloma with Extramedullary Disease
title_sort (68)ga-pentixafor pet/ct may fail to detect recurrent multiple myeloma with extramedullary disease
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001095/
https://www.ncbi.nlm.nih.gov/pubmed/36900014
http://dx.doi.org/10.3390/diagnostics13050871
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