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Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study
Physical activity (PA) plays an important role in affect processing. Studies describe the orbitofrontal cortex (OFC) as a major hub for emotion processing and the pathophysiology of affective disorders. Subregions of the OFC show diverse functional connectivity (FC) topographies, but the effect of c...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001322/ https://www.ncbi.nlm.nih.gov/pubmed/36900693 http://dx.doi.org/10.3390/healthcare11050689 |
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author | Claus, Jannik Upadhyay, Neeraj Maurer, Angelika Klein, Julian Scheef, Lukas Daamen, Marcel Martin, Jason Anthony Stirnberg, Rüdiger Radbruch, Alexander Attenberger, Ulrike Stöcker, Tony Boecker, Henning |
author_facet | Claus, Jannik Upadhyay, Neeraj Maurer, Angelika Klein, Julian Scheef, Lukas Daamen, Marcel Martin, Jason Anthony Stirnberg, Rüdiger Radbruch, Alexander Attenberger, Ulrike Stöcker, Tony Boecker, Henning |
author_sort | Claus, Jannik |
collection | PubMed |
description | Physical activity (PA) plays an important role in affect processing. Studies describe the orbitofrontal cortex (OFC) as a major hub for emotion processing and the pathophysiology of affective disorders. Subregions of the OFC show diverse functional connectivity (FC) topographies, but the effect of chronic PA on subregional OFC FC still lacks scientific understanding. Therefore, we aimed at investigating the effects of regular PA on the FC topographies of OFC subregions in healthy individuals within a longitudinal randomized controlled exercise study. Participants (age: 18–35 years) were randomly assigned to either an intervention group (IG; N = 18) or a control group (CG; N = 10). Fitness assessments, mood questionnaires, and resting state functional magnetic resonance imaging (rsfMRI) were performed four times over the duration of 6 months. Using a detailed parcellation of the OFC, we created subregional FC topography maps at each time point and applied a linear mixed model to assess the effects of regular PA. The posterior–lateral right OFC showed a group and time interaction, revealing decreased FC with the left dorsolateral prefrontal cortex in the IG, while FC in the CG increased. Group and time interaction in the anterior–lateral right OFC with the right middle frontal gyrus was driven by increased FC in the IG. The posterior–lateral left OFC showed a group and time interaction based on differential change in FC to the left postcentral gyrus and the right occipital gyrus. This study emphasized regionally distinctive FC changes induced by PA within the lateral OFC territory, while providing aspects for further research. |
format | Online Article Text |
id | pubmed-10001322 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100013222023-03-11 Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study Claus, Jannik Upadhyay, Neeraj Maurer, Angelika Klein, Julian Scheef, Lukas Daamen, Marcel Martin, Jason Anthony Stirnberg, Rüdiger Radbruch, Alexander Attenberger, Ulrike Stöcker, Tony Boecker, Henning Healthcare (Basel) Article Physical activity (PA) plays an important role in affect processing. Studies describe the orbitofrontal cortex (OFC) as a major hub for emotion processing and the pathophysiology of affective disorders. Subregions of the OFC show diverse functional connectivity (FC) topographies, but the effect of chronic PA on subregional OFC FC still lacks scientific understanding. Therefore, we aimed at investigating the effects of regular PA on the FC topographies of OFC subregions in healthy individuals within a longitudinal randomized controlled exercise study. Participants (age: 18–35 years) were randomly assigned to either an intervention group (IG; N = 18) or a control group (CG; N = 10). Fitness assessments, mood questionnaires, and resting state functional magnetic resonance imaging (rsfMRI) were performed four times over the duration of 6 months. Using a detailed parcellation of the OFC, we created subregional FC topography maps at each time point and applied a linear mixed model to assess the effects of regular PA. The posterior–lateral right OFC showed a group and time interaction, revealing decreased FC with the left dorsolateral prefrontal cortex in the IG, while FC in the CG increased. Group and time interaction in the anterior–lateral right OFC with the right middle frontal gyrus was driven by increased FC in the IG. The posterior–lateral left OFC showed a group and time interaction based on differential change in FC to the left postcentral gyrus and the right occipital gyrus. This study emphasized regionally distinctive FC changes induced by PA within the lateral OFC territory, while providing aspects for further research. MDPI 2023-02-26 /pmc/articles/PMC10001322/ /pubmed/36900693 http://dx.doi.org/10.3390/healthcare11050689 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Claus, Jannik Upadhyay, Neeraj Maurer, Angelika Klein, Julian Scheef, Lukas Daamen, Marcel Martin, Jason Anthony Stirnberg, Rüdiger Radbruch, Alexander Attenberger, Ulrike Stöcker, Tony Boecker, Henning Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study |
title | Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study |
title_full | Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study |
title_fullStr | Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study |
title_full_unstemmed | Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study |
title_short | Physical Activity Alters Functional Connectivity of Orbitofrontal Cortex Subdivisions in Healthy Young Adults: A Longitudinal fMRI Study |
title_sort | physical activity alters functional connectivity of orbitofrontal cortex subdivisions in healthy young adults: a longitudinal fmri study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001322/ https://www.ncbi.nlm.nih.gov/pubmed/36900693 http://dx.doi.org/10.3390/healthcare11050689 |
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