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Geographical Disparities in Esophageal Cancer Incidence and Mortality in the United States

Background: Our previous research on neuroendocrine and gastric cancers has shown that patients living in rural areas have worse outcomes than urban patients. This study aimed to investigate the geographic and sociodemographic disparities in esophageal cancer patients. Methods: We conducted a retros...

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Autores principales: Vedire, Yeshwanth, Rana, Navpreet, Groman, Adrienne, Siromoni, Beas, Yendamuri, Sai, Mukherjee, Sarbajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001323/
https://www.ncbi.nlm.nih.gov/pubmed/36900690
http://dx.doi.org/10.3390/healthcare11050685
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author Vedire, Yeshwanth
Rana, Navpreet
Groman, Adrienne
Siromoni, Beas
Yendamuri, Sai
Mukherjee, Sarbajit
author_facet Vedire, Yeshwanth
Rana, Navpreet
Groman, Adrienne
Siromoni, Beas
Yendamuri, Sai
Mukherjee, Sarbajit
author_sort Vedire, Yeshwanth
collection PubMed
description Background: Our previous research on neuroendocrine and gastric cancers has shown that patients living in rural areas have worse outcomes than urban patients. This study aimed to investigate the geographic and sociodemographic disparities in esophageal cancer patients. Methods: We conducted a retrospective study on esophageal cancer patients between 1975 and 2016 using the Surveillance, Epidemiology, and End Results database. Both univariate and multivariable analyses were performed to evaluate overall survival (OS) and disease-specific survival (DSS) between patients residing in rural (RA) and urban (MA) areas. Further, we used the National Cancer Database to understand differences in various quality of care metrics based on residence. Results: N = 49,421 (RA [12%]; MA [88%]). The incidence and mortality rates were consistently higher during the study period in RA. Patients living in RA were more commonly males (p < 0.001), Caucasian (p < 0.001), and had adenocarcinoma (p < 0.001). Multivariable analysis showed that RA had worse OS (HR = 1.08; p < 0.01) and DSS (HR = 1.07; p < 0.01). Quality of care was similar, except RA patients were more likely to be treated at a community hospital (p < 0.001). Conclusions: Our study identified geographic disparities in esophageal cancer incidence and outcomes despite the similar quality of care. Future research is needed to understand and attenuate such disparities.
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spelling pubmed-100013232023-03-11 Geographical Disparities in Esophageal Cancer Incidence and Mortality in the United States Vedire, Yeshwanth Rana, Navpreet Groman, Adrienne Siromoni, Beas Yendamuri, Sai Mukherjee, Sarbajit Healthcare (Basel) Article Background: Our previous research on neuroendocrine and gastric cancers has shown that patients living in rural areas have worse outcomes than urban patients. This study aimed to investigate the geographic and sociodemographic disparities in esophageal cancer patients. Methods: We conducted a retrospective study on esophageal cancer patients between 1975 and 2016 using the Surveillance, Epidemiology, and End Results database. Both univariate and multivariable analyses were performed to evaluate overall survival (OS) and disease-specific survival (DSS) between patients residing in rural (RA) and urban (MA) areas. Further, we used the National Cancer Database to understand differences in various quality of care metrics based on residence. Results: N = 49,421 (RA [12%]; MA [88%]). The incidence and mortality rates were consistently higher during the study period in RA. Patients living in RA were more commonly males (p < 0.001), Caucasian (p < 0.001), and had adenocarcinoma (p < 0.001). Multivariable analysis showed that RA had worse OS (HR = 1.08; p < 0.01) and DSS (HR = 1.07; p < 0.01). Quality of care was similar, except RA patients were more likely to be treated at a community hospital (p < 0.001). Conclusions: Our study identified geographic disparities in esophageal cancer incidence and outcomes despite the similar quality of care. Future research is needed to understand and attenuate such disparities. MDPI 2023-02-25 /pmc/articles/PMC10001323/ /pubmed/36900690 http://dx.doi.org/10.3390/healthcare11050685 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vedire, Yeshwanth
Rana, Navpreet
Groman, Adrienne
Siromoni, Beas
Yendamuri, Sai
Mukherjee, Sarbajit
Geographical Disparities in Esophageal Cancer Incidence and Mortality in the United States
title Geographical Disparities in Esophageal Cancer Incidence and Mortality in the United States
title_full Geographical Disparities in Esophageal Cancer Incidence and Mortality in the United States
title_fullStr Geographical Disparities in Esophageal Cancer Incidence and Mortality in the United States
title_full_unstemmed Geographical Disparities in Esophageal Cancer Incidence and Mortality in the United States
title_short Geographical Disparities in Esophageal Cancer Incidence and Mortality in the United States
title_sort geographical disparities in esophageal cancer incidence and mortality in the united states
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001323/
https://www.ncbi.nlm.nih.gov/pubmed/36900690
http://dx.doi.org/10.3390/healthcare11050685
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