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Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders

The world population is aging rapidly, and increasing lifespan exacerbates the burden of age-related health issues. On the other hand, premature aging has begun to be a problem, with increasing numbers of younger people suffering aging-related symptoms. Advanced aging is caused by a combination of f...

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Detalles Bibliográficos
Autores principales: Abdelhamid, Rehab F., Nagano, Seiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001353/
https://www.ncbi.nlm.nih.gov/pubmed/36899889
http://dx.doi.org/10.3390/cells12050753
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author Abdelhamid, Rehab F.
Nagano, Seiichi
author_facet Abdelhamid, Rehab F.
Nagano, Seiichi
author_sort Abdelhamid, Rehab F.
collection PubMed
description The world population is aging rapidly, and increasing lifespan exacerbates the burden of age-related health issues. On the other hand, premature aging has begun to be a problem, with increasing numbers of younger people suffering aging-related symptoms. Advanced aging is caused by a combination of factors: lifestyle, diet, external and internal factors, as well as oxidative stress (OS). Although OS is the most researched aging factor, it is also the least understood. OS is important not only in relation to aging but also due to its strong impact on neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), and Parkinson’s disease (PD). In this review, we will discuss the aging process in relation to OS, the function of OS in neurodegenerative disorders, and prospective therapeutics capable of relieving neurodegenerative symptoms associated with the pro-oxidative condition.
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spelling pubmed-100013532023-03-11 Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders Abdelhamid, Rehab F. Nagano, Seiichi Cells Review The world population is aging rapidly, and increasing lifespan exacerbates the burden of age-related health issues. On the other hand, premature aging has begun to be a problem, with increasing numbers of younger people suffering aging-related symptoms. Advanced aging is caused by a combination of factors: lifestyle, diet, external and internal factors, as well as oxidative stress (OS). Although OS is the most researched aging factor, it is also the least understood. OS is important not only in relation to aging but also due to its strong impact on neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), and Parkinson’s disease (PD). In this review, we will discuss the aging process in relation to OS, the function of OS in neurodegenerative disorders, and prospective therapeutics capable of relieving neurodegenerative symptoms associated with the pro-oxidative condition. MDPI 2023-02-27 /pmc/articles/PMC10001353/ /pubmed/36899889 http://dx.doi.org/10.3390/cells12050753 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abdelhamid, Rehab F.
Nagano, Seiichi
Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders
title Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders
title_full Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders
title_fullStr Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders
title_full_unstemmed Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders
title_short Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders
title_sort crosstalk between oxidative stress and aging in neurodegeneration disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001353/
https://www.ncbi.nlm.nih.gov/pubmed/36899889
http://dx.doi.org/10.3390/cells12050753
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