Cargando…

Determinants of Acquisition, Persistence, and Clearance of Oncogenic Cervical Human Papillomavirus Infection in the Philippines Using a Multi-Omics Approach: DEFEAT HPV Study Protocol

HPV infection is one of the most studied risk factors in cervical cancer—the second most common cancer site and cause of death due to cancer in the Philippines. However, there is a lack of population-based epidemiological data on cervical HPV infection in the Philippines. Local reports on co-infecti...

Descripción completa

Detalles Bibliográficos
Autores principales: de Paz-Silava, Sheriah Laine M., Tabios, Ian Kim B., Tantengco, Ourlad Alzeus G., Climacosa, Fresthel Monica M., Velayo, Clarissa L., Lintao, Ryan C. V., Cando, Leslie Faye T., Perias, Glenmarie Angelica S., Idolor, Maria Isabel C., Francisco, Abialbon G., Catral, Charlene Divine M., Chiong, Charlotte M., Dalmacio, Leslie Michele M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001359/
https://www.ncbi.nlm.nih.gov/pubmed/36900663
http://dx.doi.org/10.3390/healthcare11050658
_version_ 1784904117401944064
author de Paz-Silava, Sheriah Laine M.
Tabios, Ian Kim B.
Tantengco, Ourlad Alzeus G.
Climacosa, Fresthel Monica M.
Velayo, Clarissa L.
Lintao, Ryan C. V.
Cando, Leslie Faye T.
Perias, Glenmarie Angelica S.
Idolor, Maria Isabel C.
Francisco, Abialbon G.
Catral, Charlene Divine M.
Chiong, Charlotte M.
Dalmacio, Leslie Michele M.
author_facet de Paz-Silava, Sheriah Laine M.
Tabios, Ian Kim B.
Tantengco, Ourlad Alzeus G.
Climacosa, Fresthel Monica M.
Velayo, Clarissa L.
Lintao, Ryan C. V.
Cando, Leslie Faye T.
Perias, Glenmarie Angelica S.
Idolor, Maria Isabel C.
Francisco, Abialbon G.
Catral, Charlene Divine M.
Chiong, Charlotte M.
Dalmacio, Leslie Michele M.
author_sort de Paz-Silava, Sheriah Laine M.
collection PubMed
description HPV infection is one of the most studied risk factors in cervical cancer—the second most common cancer site and cause of death due to cancer in the Philippines. However, there is a lack of population-based epidemiological data on cervical HPV infection in the Philippines. Local reports on co-infections with other lower genital tract pathogens, commonly reported globally, are also lacking, which emphasizes the need to increase efforts in targeting HPV prevalence, genotype, and distribution. Hence, we aim to determine the molecular epidemiology and natural history of HPV infection among reproductive-age Filipino women using a community-based prospective cohort design. Women from rural and urban centers will be screened until the target sample size of 110 HPV-positive women (55 from rural sites and 55 from urban sites) is reached. Cervical and vaginal swabs will be collected from all screened participants. For HPV-positive patients, HPV genotypes will be determined. One hundred ten healthy controls will be selected from previously screened volunteers. The cases and controls will comprise the multi-omics subset of participants and will be followed up after 6 and 12 months for repeat HPV screening. Metagenomic and metabolomic analyses of the vaginal swabs will also be performed at baseline, after 6 months, and after 12 months. The results of this study will update the prevalence and genotypic distribution of cervical HPV infection among Filipino women, determine whether the current vaccines used for HPV vaccination programs capture the most prevalent high-risk HPV genotypes in the country, and identify vaginal community state types and bacterial taxa associated with the natural history of cervical HPV infection. The results of this study will be used as the basis for developing a biomarker that can help predict the risk of developing persistent cervical HPV infection in Filipino women.
format Online
Article
Text
id pubmed-10001359
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100013592023-03-11 Determinants of Acquisition, Persistence, and Clearance of Oncogenic Cervical Human Papillomavirus Infection in the Philippines Using a Multi-Omics Approach: DEFEAT HPV Study Protocol de Paz-Silava, Sheriah Laine M. Tabios, Ian Kim B. Tantengco, Ourlad Alzeus G. Climacosa, Fresthel Monica M. Velayo, Clarissa L. Lintao, Ryan C. V. Cando, Leslie Faye T. Perias, Glenmarie Angelica S. Idolor, Maria Isabel C. Francisco, Abialbon G. Catral, Charlene Divine M. Chiong, Charlotte M. Dalmacio, Leslie Michele M. Healthcare (Basel) Study Protocol HPV infection is one of the most studied risk factors in cervical cancer—the second most common cancer site and cause of death due to cancer in the Philippines. However, there is a lack of population-based epidemiological data on cervical HPV infection in the Philippines. Local reports on co-infections with other lower genital tract pathogens, commonly reported globally, are also lacking, which emphasizes the need to increase efforts in targeting HPV prevalence, genotype, and distribution. Hence, we aim to determine the molecular epidemiology and natural history of HPV infection among reproductive-age Filipino women using a community-based prospective cohort design. Women from rural and urban centers will be screened until the target sample size of 110 HPV-positive women (55 from rural sites and 55 from urban sites) is reached. Cervical and vaginal swabs will be collected from all screened participants. For HPV-positive patients, HPV genotypes will be determined. One hundred ten healthy controls will be selected from previously screened volunteers. The cases and controls will comprise the multi-omics subset of participants and will be followed up after 6 and 12 months for repeat HPV screening. Metagenomic and metabolomic analyses of the vaginal swabs will also be performed at baseline, after 6 months, and after 12 months. The results of this study will update the prevalence and genotypic distribution of cervical HPV infection among Filipino women, determine whether the current vaccines used for HPV vaccination programs capture the most prevalent high-risk HPV genotypes in the country, and identify vaginal community state types and bacterial taxa associated with the natural history of cervical HPV infection. The results of this study will be used as the basis for developing a biomarker that can help predict the risk of developing persistent cervical HPV infection in Filipino women. MDPI 2023-02-23 /pmc/articles/PMC10001359/ /pubmed/36900663 http://dx.doi.org/10.3390/healthcare11050658 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Study Protocol
de Paz-Silava, Sheriah Laine M.
Tabios, Ian Kim B.
Tantengco, Ourlad Alzeus G.
Climacosa, Fresthel Monica M.
Velayo, Clarissa L.
Lintao, Ryan C. V.
Cando, Leslie Faye T.
Perias, Glenmarie Angelica S.
Idolor, Maria Isabel C.
Francisco, Abialbon G.
Catral, Charlene Divine M.
Chiong, Charlotte M.
Dalmacio, Leslie Michele M.
Determinants of Acquisition, Persistence, and Clearance of Oncogenic Cervical Human Papillomavirus Infection in the Philippines Using a Multi-Omics Approach: DEFEAT HPV Study Protocol
title Determinants of Acquisition, Persistence, and Clearance of Oncogenic Cervical Human Papillomavirus Infection in the Philippines Using a Multi-Omics Approach: DEFEAT HPV Study Protocol
title_full Determinants of Acquisition, Persistence, and Clearance of Oncogenic Cervical Human Papillomavirus Infection in the Philippines Using a Multi-Omics Approach: DEFEAT HPV Study Protocol
title_fullStr Determinants of Acquisition, Persistence, and Clearance of Oncogenic Cervical Human Papillomavirus Infection in the Philippines Using a Multi-Omics Approach: DEFEAT HPV Study Protocol
title_full_unstemmed Determinants of Acquisition, Persistence, and Clearance of Oncogenic Cervical Human Papillomavirus Infection in the Philippines Using a Multi-Omics Approach: DEFEAT HPV Study Protocol
title_short Determinants of Acquisition, Persistence, and Clearance of Oncogenic Cervical Human Papillomavirus Infection in the Philippines Using a Multi-Omics Approach: DEFEAT HPV Study Protocol
title_sort determinants of acquisition, persistence, and clearance of oncogenic cervical human papillomavirus infection in the philippines using a multi-omics approach: defeat hpv study protocol
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001359/
https://www.ncbi.nlm.nih.gov/pubmed/36900663
http://dx.doi.org/10.3390/healthcare11050658
work_keys_str_mv AT depazsilavasheriahlainem determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol
AT tabiosiankimb determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol
AT tantengcoourladalzeusg determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol
AT climacosafresthelmonicam determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol
AT velayoclarissal determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol
AT lintaoryancv determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol
AT candolesliefayet determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol
AT periasglenmarieangelicas determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol
AT idolormariaisabelc determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol
AT franciscoabialbong determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol
AT catralcharlenedivinem determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol
AT chiongcharlottem determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol
AT dalmaciolesliemichelem determinantsofacquisitionpersistenceandclearanceofoncogeniccervicalhumanpapillomavirusinfectioninthephilippinesusingamultiomicsapproachdefeathpvstudyprotocol