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Extrahepatic Distal Cholangiocarcinoma vs. Pancreatic Ductal Adenocarcinoma: Histology and Molecular Profiling for Differential Diagnosis and Treatment
SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) and distal cholangiocarcinoma (dCCA) are very aggressive neoplasms. However, effective treatments are still limited. Starting from a common embryogenesis of the tissue of origin, these two cancer types share several histomolecular features, whi...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001378/ https://www.ncbi.nlm.nih.gov/pubmed/36900245 http://dx.doi.org/10.3390/cancers15051454 |
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author | Gkountakos, Anastasios Martelli, Filippo M. Silvestris, Nicola Bevere, Michele De Bellis, Mario Alaimo, Laura Sapuppo, Elena Masetto, Francesca Mombello, Aldo Simbolo, Michele Bariani, Elena Milella, Michele Fassan, Matteo Scarpa, Aldo Luchini, Claudio |
author_facet | Gkountakos, Anastasios Martelli, Filippo M. Silvestris, Nicola Bevere, Michele De Bellis, Mario Alaimo, Laura Sapuppo, Elena Masetto, Francesca Mombello, Aldo Simbolo, Michele Bariani, Elena Milella, Michele Fassan, Matteo Scarpa, Aldo Luchini, Claudio |
author_sort | Gkountakos, Anastasios |
collection | PubMed |
description | SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) and distal cholangiocarcinoma (dCCA) are very aggressive neoplasms. However, effective treatments are still limited. Starting from a common embryogenesis of the tissue of origin, these two cancer types share several histomolecular features, which renders a differential diagnosis challenging. However, there are also significant differences, with a potential clinical impact. Here, we present the main similarities and differences between PDAC and dCCA, also discussing the most important implications derived from this challenging differential diagnosis. ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) and distal cholangiocarcinoma (dCCA) are very aggressive tumors with a high mortality rate. Pancreas and distal bile ducts share a common embryonic development. Hence, PDAC and dCCA exhibit similar histological features that make a differential diagnosis during routine diagnostic practice challenging. However, there are also significant differences, with potential clinical implications. Even if PDAC and dCCA are generally associated with poor survival, patients with dCCA seem to present a better prognosis. Moreover, although precision oncology-based approaches are still limited in both entities, their most important targets are different and include alterations affecting BRCA1/2 and related genes in PDAC, as well as HER2 amplification in dCCA. Along this line, microsatellite instability represents a potential contact point in terms of tailored treatments, but its prevalence is very low in both tumor types. This review aims at defining the most important similarities and differences in terms of clinicopathological and molecular features between these two entities, also discussing the main theranostic implications derived from this challenging differential diagnosis. |
format | Online Article Text |
id | pubmed-10001378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100013782023-03-11 Extrahepatic Distal Cholangiocarcinoma vs. Pancreatic Ductal Adenocarcinoma: Histology and Molecular Profiling for Differential Diagnosis and Treatment Gkountakos, Anastasios Martelli, Filippo M. Silvestris, Nicola Bevere, Michele De Bellis, Mario Alaimo, Laura Sapuppo, Elena Masetto, Francesca Mombello, Aldo Simbolo, Michele Bariani, Elena Milella, Michele Fassan, Matteo Scarpa, Aldo Luchini, Claudio Cancers (Basel) Review SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) and distal cholangiocarcinoma (dCCA) are very aggressive neoplasms. However, effective treatments are still limited. Starting from a common embryogenesis of the tissue of origin, these two cancer types share several histomolecular features, which renders a differential diagnosis challenging. However, there are also significant differences, with a potential clinical impact. Here, we present the main similarities and differences between PDAC and dCCA, also discussing the most important implications derived from this challenging differential diagnosis. ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) and distal cholangiocarcinoma (dCCA) are very aggressive tumors with a high mortality rate. Pancreas and distal bile ducts share a common embryonic development. Hence, PDAC and dCCA exhibit similar histological features that make a differential diagnosis during routine diagnostic practice challenging. However, there are also significant differences, with potential clinical implications. Even if PDAC and dCCA are generally associated with poor survival, patients with dCCA seem to present a better prognosis. Moreover, although precision oncology-based approaches are still limited in both entities, their most important targets are different and include alterations affecting BRCA1/2 and related genes in PDAC, as well as HER2 amplification in dCCA. Along this line, microsatellite instability represents a potential contact point in terms of tailored treatments, but its prevalence is very low in both tumor types. This review aims at defining the most important similarities and differences in terms of clinicopathological and molecular features between these two entities, also discussing the main theranostic implications derived from this challenging differential diagnosis. MDPI 2023-02-24 /pmc/articles/PMC10001378/ /pubmed/36900245 http://dx.doi.org/10.3390/cancers15051454 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gkountakos, Anastasios Martelli, Filippo M. Silvestris, Nicola Bevere, Michele De Bellis, Mario Alaimo, Laura Sapuppo, Elena Masetto, Francesca Mombello, Aldo Simbolo, Michele Bariani, Elena Milella, Michele Fassan, Matteo Scarpa, Aldo Luchini, Claudio Extrahepatic Distal Cholangiocarcinoma vs. Pancreatic Ductal Adenocarcinoma: Histology and Molecular Profiling for Differential Diagnosis and Treatment |
title | Extrahepatic Distal Cholangiocarcinoma vs. Pancreatic Ductal Adenocarcinoma: Histology and Molecular Profiling for Differential Diagnosis and Treatment |
title_full | Extrahepatic Distal Cholangiocarcinoma vs. Pancreatic Ductal Adenocarcinoma: Histology and Molecular Profiling for Differential Diagnosis and Treatment |
title_fullStr | Extrahepatic Distal Cholangiocarcinoma vs. Pancreatic Ductal Adenocarcinoma: Histology and Molecular Profiling for Differential Diagnosis and Treatment |
title_full_unstemmed | Extrahepatic Distal Cholangiocarcinoma vs. Pancreatic Ductal Adenocarcinoma: Histology and Molecular Profiling for Differential Diagnosis and Treatment |
title_short | Extrahepatic Distal Cholangiocarcinoma vs. Pancreatic Ductal Adenocarcinoma: Histology and Molecular Profiling for Differential Diagnosis and Treatment |
title_sort | extrahepatic distal cholangiocarcinoma vs. pancreatic ductal adenocarcinoma: histology and molecular profiling for differential diagnosis and treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001378/ https://www.ncbi.nlm.nih.gov/pubmed/36900245 http://dx.doi.org/10.3390/cancers15051454 |
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