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Melanoma Mortality Trends in 28 European Countries: A Retrospective Analysis for the Years 1960–2020

SIMPLE SUMMARY: Efficient health interventions in individual populations should be based on evidence-based data. Our study provides new insights on melanoma (except primary uveal melanoma) mortality trends in European Union (EU) countries, as well as in three non-EU countries, from a wide-time persp...

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Autores principales: Koczkodaj, Paweł, Sulkowska, Urszula, Didkowska, Joanna, Rutkowski, Piotr, Mańczuk, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001381/
https://www.ncbi.nlm.nih.gov/pubmed/36900305
http://dx.doi.org/10.3390/cancers15051514
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author Koczkodaj, Paweł
Sulkowska, Urszula
Didkowska, Joanna
Rutkowski, Piotr
Mańczuk, Marta
author_facet Koczkodaj, Paweł
Sulkowska, Urszula
Didkowska, Joanna
Rutkowski, Piotr
Mańczuk, Marta
author_sort Koczkodaj, Paweł
collection PubMed
description SIMPLE SUMMARY: Efficient health interventions in individual populations should be based on evidence-based data. Our study provides new insights on melanoma (except primary uveal melanoma) mortality trends in European Union (EU) countries, as well as in three non-EU countries, from a wide-time perspective (1960–2020), by sex and age groups. To the best knowledge, our study is the most up-to-date and broad analysis of melanoma mortality in Europe. It can be used as a reference for public-health actions aiming at a national and international melanoma-mortality reduction. Investigated melanoma-mortality trends vary in individual countries and age groups; however, a highly concerning phenomenon—an increasing melanoma mortality in both sexes—was observed in the case of 7 countries for the younger age group and 26 countries for the older one. There is a need for coordinated systemic actions to address this issue. ABSTRACT: Background: In 2020, in 27 European Union (EU) Member States, melanoma accounted for 4% of all new cancer cases and 1.3% of all cancer deaths, making melanoma the fifth most common malignancy and placing it in the 15 most frequent causes of cancer deaths in the EU-27. The main aim of our study was to investigate melanoma mortality trends in 25 EU Member States and three non-EU countries (Norway, Russia, and Switzerland) in a broad time perspective (1960–2020) in a younger (45–74 years old) vs. older age group (75+). Methods: We identified melanoma deaths defined by ICD-10 codes C-43 for individuals aged 45–74 and 75+ years old between 1960–2020 in 25 EU Member States (excluding Iceland, Luxembourg, and Malta) and in 3 non-EU countries—Norway, Russia, and Switzerland. Age-standardized melanoma mortality rates (ASR) were computed using the direct age-standardization for Segi’s World Standard Population. To determine melanoma-mortality trends with 95% confidence intervals (CI), Joinpoint regression was applied. Our analysis used the Join-point Regression Program, version 4.3.1.0 (National Cancer Institute, Bethesda, MD, USA). Results: Regardless of the considered age groups, in all investigated countries, in general, melanoma standardized mortality rates were higher for men than women. Considering the age group 45–74, the highest number of countries was characterized by decreasing melanoma-mortality trends in both sexes—14 countries. Contrarily, the highest representation of countries in the age group 75+ was connected with increasing melanoma-mortality trends in both sexes—26 countries. Moreover, considering the older age group—75+—there was no country with a decreasing melanoma mortality in both sexes. Conclusions: Investigated melanoma-mortality trends vary in individual countries and age groups; however, a highly concerning phenomenon—increasing melanoma-mortality rates in both sexes—was observed in 7 countries for the younger age group and in as many as 26 countries for the older age group. There is a need for coordinated public-health actions to address this issue.
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spelling pubmed-100013812023-03-11 Melanoma Mortality Trends in 28 European Countries: A Retrospective Analysis for the Years 1960–2020 Koczkodaj, Paweł Sulkowska, Urszula Didkowska, Joanna Rutkowski, Piotr Mańczuk, Marta Cancers (Basel) Article SIMPLE SUMMARY: Efficient health interventions in individual populations should be based on evidence-based data. Our study provides new insights on melanoma (except primary uveal melanoma) mortality trends in European Union (EU) countries, as well as in three non-EU countries, from a wide-time perspective (1960–2020), by sex and age groups. To the best knowledge, our study is the most up-to-date and broad analysis of melanoma mortality in Europe. It can be used as a reference for public-health actions aiming at a national and international melanoma-mortality reduction. Investigated melanoma-mortality trends vary in individual countries and age groups; however, a highly concerning phenomenon—an increasing melanoma mortality in both sexes—was observed in the case of 7 countries for the younger age group and 26 countries for the older one. There is a need for coordinated systemic actions to address this issue. ABSTRACT: Background: In 2020, in 27 European Union (EU) Member States, melanoma accounted for 4% of all new cancer cases and 1.3% of all cancer deaths, making melanoma the fifth most common malignancy and placing it in the 15 most frequent causes of cancer deaths in the EU-27. The main aim of our study was to investigate melanoma mortality trends in 25 EU Member States and three non-EU countries (Norway, Russia, and Switzerland) in a broad time perspective (1960–2020) in a younger (45–74 years old) vs. older age group (75+). Methods: We identified melanoma deaths defined by ICD-10 codes C-43 for individuals aged 45–74 and 75+ years old between 1960–2020 in 25 EU Member States (excluding Iceland, Luxembourg, and Malta) and in 3 non-EU countries—Norway, Russia, and Switzerland. Age-standardized melanoma mortality rates (ASR) were computed using the direct age-standardization for Segi’s World Standard Population. To determine melanoma-mortality trends with 95% confidence intervals (CI), Joinpoint regression was applied. Our analysis used the Join-point Regression Program, version 4.3.1.0 (National Cancer Institute, Bethesda, MD, USA). Results: Regardless of the considered age groups, in all investigated countries, in general, melanoma standardized mortality rates were higher for men than women. Considering the age group 45–74, the highest number of countries was characterized by decreasing melanoma-mortality trends in both sexes—14 countries. Contrarily, the highest representation of countries in the age group 75+ was connected with increasing melanoma-mortality trends in both sexes—26 countries. Moreover, considering the older age group—75+—there was no country with a decreasing melanoma mortality in both sexes. Conclusions: Investigated melanoma-mortality trends vary in individual countries and age groups; however, a highly concerning phenomenon—increasing melanoma-mortality rates in both sexes—was observed in 7 countries for the younger age group and in as many as 26 countries for the older age group. There is a need for coordinated public-health actions to address this issue. MDPI 2023-02-28 /pmc/articles/PMC10001381/ /pubmed/36900305 http://dx.doi.org/10.3390/cancers15051514 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Koczkodaj, Paweł
Sulkowska, Urszula
Didkowska, Joanna
Rutkowski, Piotr
Mańczuk, Marta
Melanoma Mortality Trends in 28 European Countries: A Retrospective Analysis for the Years 1960–2020
title Melanoma Mortality Trends in 28 European Countries: A Retrospective Analysis for the Years 1960–2020
title_full Melanoma Mortality Trends in 28 European Countries: A Retrospective Analysis for the Years 1960–2020
title_fullStr Melanoma Mortality Trends in 28 European Countries: A Retrospective Analysis for the Years 1960–2020
title_full_unstemmed Melanoma Mortality Trends in 28 European Countries: A Retrospective Analysis for the Years 1960–2020
title_short Melanoma Mortality Trends in 28 European Countries: A Retrospective Analysis for the Years 1960–2020
title_sort melanoma mortality trends in 28 european countries: a retrospective analysis for the years 1960–2020
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001381/
https://www.ncbi.nlm.nih.gov/pubmed/36900305
http://dx.doi.org/10.3390/cancers15051514
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