A Novel Combination of Sotorasib and Metformin Enhances Cytotoxicity and Apoptosis in KRAS-Mutated Non-Small Cell Lung Cancer Cell Lines through MAPK and P70S6K Inhibition

Novel inhibitors of KRAS with G12C mutation (sotorasib) have demonstrated short-lasting responses due to resistance mediated by the AKT-mTOR-P70S6K pathway. In this context, metformin is a promising candidate to break this resistance by inhibiting mTOR and P70S6K. Therefore, this project aimed to ex...

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Detalles Bibliográficos
Autores principales: Barrios-Bernal, Pedro, Lucio-Lozada, José, Ramos-Ramírez, Maritza, Hernández-Pedro, Norma, Arrieta, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001819/
https://www.ncbi.nlm.nih.gov/pubmed/36901764
http://dx.doi.org/10.3390/ijms24054331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001819/
https://www.ncbi.nlm.nih.gov/pubmed/36901764
http://dx.doi.org/10.3390/ijms24054331

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