Cargando…
The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study
Background: Cardiovascular (CV) risk factors, causing endothelial dysfunction (ED) and left ventricular diastolic dysfunction (LVDD), contribute to an increased risk of heart failure (HF). The aim of this study was to determine the relationship between the occurrence of LVDD and ED with CV risk asse...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001866/ https://www.ncbi.nlm.nih.gov/pubmed/36901443 http://dx.doi.org/10.3390/ijerph20054433 |
_version_ | 1784904249651494912 |
---|---|
author | Sušić, Livija Maričić, Lana Šahinović, Ines Kralik, Kristina Klobučar, Lucija Ćosić, Mateja Sušić, Tihomir Vincelj, Josip Burić, Antonio Burić, Marko Lukić, Matea |
author_facet | Sušić, Livija Maričić, Lana Šahinović, Ines Kralik, Kristina Klobučar, Lucija Ćosić, Mateja Sušić, Tihomir Vincelj, Josip Burić, Antonio Burić, Marko Lukić, Matea |
author_sort | Sušić, Livija |
collection | PubMed |
description | Background: Cardiovascular (CV) risk factors, causing endothelial dysfunction (ED) and left ventricular diastolic dysfunction (LVDD), contribute to an increased risk of heart failure (HF). The aim of this study was to determine the relationship between the occurrence of LVDD and ED with CV risk assessed by the Systematic Coronary Risk Evaluation2 (SCORE2) algorithm and HF. Methods: In the period from November 2019 to May 2022, a cross-sectional study that included 178 middle-aged adults was conducted. Transthoracic echocardiography (TTE) was used to assess left ventricular (LV) diastolic and systolic function. ED was assessed using the plasma values of asymmetric dimethylarginine (ADMA) and was determined using the ELISA method. Results: The majority of subjects with LVDD grades 2 and 3 had high/very high SCORE2, developed HF and all were taking medication (p < 0.001). They also had significantly lowest plasma ADMA values (p < 0.001). We found that the reduction of ADMA concentration is influenced by certain groups of drugs, or more significantly, by their combinations (p < 0.001). Conclusions: In our study, we confirmed a positive correlation between LVDD, HF and SCORE2 severity. The results showed a negative correlation between the biomarkers of ED, LVDD severity, HF, and SCORE2, which we believe is due to medication effects. |
format | Online Article Text |
id | pubmed-10001866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100018662023-03-11 The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study Sušić, Livija Maričić, Lana Šahinović, Ines Kralik, Kristina Klobučar, Lucija Ćosić, Mateja Sušić, Tihomir Vincelj, Josip Burić, Antonio Burić, Marko Lukić, Matea Int J Environ Res Public Health Article Background: Cardiovascular (CV) risk factors, causing endothelial dysfunction (ED) and left ventricular diastolic dysfunction (LVDD), contribute to an increased risk of heart failure (HF). The aim of this study was to determine the relationship between the occurrence of LVDD and ED with CV risk assessed by the Systematic Coronary Risk Evaluation2 (SCORE2) algorithm and HF. Methods: In the period from November 2019 to May 2022, a cross-sectional study that included 178 middle-aged adults was conducted. Transthoracic echocardiography (TTE) was used to assess left ventricular (LV) diastolic and systolic function. ED was assessed using the plasma values of asymmetric dimethylarginine (ADMA) and was determined using the ELISA method. Results: The majority of subjects with LVDD grades 2 and 3 had high/very high SCORE2, developed HF and all were taking medication (p < 0.001). They also had significantly lowest plasma ADMA values (p < 0.001). We found that the reduction of ADMA concentration is influenced by certain groups of drugs, or more significantly, by their combinations (p < 0.001). Conclusions: In our study, we confirmed a positive correlation between LVDD, HF and SCORE2 severity. The results showed a negative correlation between the biomarkers of ED, LVDD severity, HF, and SCORE2, which we believe is due to medication effects. MDPI 2023-03-01 /pmc/articles/PMC10001866/ /pubmed/36901443 http://dx.doi.org/10.3390/ijerph20054433 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sušić, Livija Maričić, Lana Šahinović, Ines Kralik, Kristina Klobučar, Lucija Ćosić, Mateja Sušić, Tihomir Vincelj, Josip Burić, Antonio Burić, Marko Lukić, Matea The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study |
title | The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study |
title_full | The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study |
title_fullStr | The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study |
title_full_unstemmed | The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study |
title_short | The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study |
title_sort | relationship of left ventricular diastolic dysfunction and asymmetrical dimethylarginine as a biomarker of endothelial dysfunction with cardiovascular risk assessed by systematic coronary risk evaluation2 algorithm and heart failure—a cross-sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001866/ https://www.ncbi.nlm.nih.gov/pubmed/36901443 http://dx.doi.org/10.3390/ijerph20054433 |
work_keys_str_mv | AT susiclivija therelationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT mariciclana therelationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT sahinovicines therelationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT kralikkristina therelationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT klobucarlucija therelationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT cosicmateja therelationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT susictihomir therelationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT vinceljjosip therelationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT buricantonio therelationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT buricmarko therelationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT lukicmatea therelationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT susiclivija relationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT mariciclana relationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT sahinovicines relationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT kralikkristina relationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT klobucarlucija relationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT cosicmateja relationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT susictihomir relationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT vinceljjosip relationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT buricantonio relationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT buricmarko relationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy AT lukicmatea relationshipofleftventriculardiastolicdysfunctionandasymmetricaldimethylarginineasabiomarkerofendothelialdysfunctionwithcardiovascularriskassessedbysystematiccoronaryriskevaluation2algorithmandheartfailureacrosssectionalstudy |