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Risk Factors for Mortality of Hospitalized Adult Patients with COVID-19 Pneumonia: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico

During the COVID-19 pandemic, the high prevalence of comorbidities and the disparities between the public and private health subsystems in Mexico substantially contributed to the severe impact of the disease. The objective of this study was to evaluate and compare the risk factors at admission for i...

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Detalles Bibliográficos
Autores principales: López-Pérez, Carlos Axel, Santa Cruz-Pavlovich, Francisco J., Montiel-Cortés, Juan Eduardo, Núñez-Muratalla, Adriana, Morán-González, Ruth Bibani, Villanueva-Gaona, Ricardo, Franco-Mojica, Xochitl, Moreno-Sandoval, Denisse Gabriela, González-Bañuelos, Joselyn Anacaren, López-Pérez, Alan Ulises, Flores-González, Marily, Grijalva-Ruiz, Cristina, Valdez-Mendoza, Edna Daniela, González-Lucano, Luis Renee, López-Zendejas, Martín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001871/
https://www.ncbi.nlm.nih.gov/pubmed/36901460
http://dx.doi.org/10.3390/ijerph20054450
Descripción
Sumario:During the COVID-19 pandemic, the high prevalence of comorbidities and the disparities between the public and private health subsystems in Mexico substantially contributed to the severe impact of the disease. The objective of this study was to evaluate and compare the risk factors at admission for in-hospital mortality of patients with COVID-19. A 2-year retrospective cohort study of hospitalized adult patients with COVID-19 pneumonia was conducted at a private tertiary care center. The study population consisted of 1258 patients with a median age of 56 ± 16.5 years, of whom 1093 recovered (86.8%) and 165 died (13.1%). In the univariate analysis, older age (p < 0.001), comorbidities such as hypertension (p < 0.001) and diabetes (p < 0.001), signs and symptoms of respiratory distress, and markers of acute inflammatory response were significantly more frequent in non-survivors. The multivariate analysis showed that older age (p < 0.001), the presence of cyanosis (p = 0.005), and previous myocardial infarction (p = 0.032) were independent predictors of mortality. In the studied cohort, the risk factors present at admission associated with increased mortality were older age, cyanosis, and a previous myocardial infarction, which can be used as valuable predictors for patients’ outcomes. To our knowledge, this is the first study analyzing predictors of mortality in COVID-19 patients attended in a private tertiary hospital in Mexico.