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Risk Factors for Mortality of Hospitalized Adult Patients with COVID-19 Pneumonia: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico

During the COVID-19 pandemic, the high prevalence of comorbidities and the disparities between the public and private health subsystems in Mexico substantially contributed to the severe impact of the disease. The objective of this study was to evaluate and compare the risk factors at admission for i...

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Autores principales: López-Pérez, Carlos Axel, Santa Cruz-Pavlovich, Francisco J., Montiel-Cortés, Juan Eduardo, Núñez-Muratalla, Adriana, Morán-González, Ruth Bibani, Villanueva-Gaona, Ricardo, Franco-Mojica, Xochitl, Moreno-Sandoval, Denisse Gabriela, González-Bañuelos, Joselyn Anacaren, López-Pérez, Alan Ulises, Flores-González, Marily, Grijalva-Ruiz, Cristina, Valdez-Mendoza, Edna Daniela, González-Lucano, Luis Renee, López-Zendejas, Martín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001871/
https://www.ncbi.nlm.nih.gov/pubmed/36901460
http://dx.doi.org/10.3390/ijerph20054450
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author López-Pérez, Carlos Axel
Santa Cruz-Pavlovich, Francisco J.
Montiel-Cortés, Juan Eduardo
Núñez-Muratalla, Adriana
Morán-González, Ruth Bibani
Villanueva-Gaona, Ricardo
Franco-Mojica, Xochitl
Moreno-Sandoval, Denisse Gabriela
González-Bañuelos, Joselyn Anacaren
López-Pérez, Alan Ulises
Flores-González, Marily
Grijalva-Ruiz, Cristina
Valdez-Mendoza, Edna Daniela
González-Lucano, Luis Renee
López-Zendejas, Martín
author_facet López-Pérez, Carlos Axel
Santa Cruz-Pavlovich, Francisco J.
Montiel-Cortés, Juan Eduardo
Núñez-Muratalla, Adriana
Morán-González, Ruth Bibani
Villanueva-Gaona, Ricardo
Franco-Mojica, Xochitl
Moreno-Sandoval, Denisse Gabriela
González-Bañuelos, Joselyn Anacaren
López-Pérez, Alan Ulises
Flores-González, Marily
Grijalva-Ruiz, Cristina
Valdez-Mendoza, Edna Daniela
González-Lucano, Luis Renee
López-Zendejas, Martín
author_sort López-Pérez, Carlos Axel
collection PubMed
description During the COVID-19 pandemic, the high prevalence of comorbidities and the disparities between the public and private health subsystems in Mexico substantially contributed to the severe impact of the disease. The objective of this study was to evaluate and compare the risk factors at admission for in-hospital mortality of patients with COVID-19. A 2-year retrospective cohort study of hospitalized adult patients with COVID-19 pneumonia was conducted at a private tertiary care center. The study population consisted of 1258 patients with a median age of 56 ± 16.5 years, of whom 1093 recovered (86.8%) and 165 died (13.1%). In the univariate analysis, older age (p < 0.001), comorbidities such as hypertension (p < 0.001) and diabetes (p < 0.001), signs and symptoms of respiratory distress, and markers of acute inflammatory response were significantly more frequent in non-survivors. The multivariate analysis showed that older age (p < 0.001), the presence of cyanosis (p = 0.005), and previous myocardial infarction (p = 0.032) were independent predictors of mortality. In the studied cohort, the risk factors present at admission associated with increased mortality were older age, cyanosis, and a previous myocardial infarction, which can be used as valuable predictors for patients’ outcomes. To our knowledge, this is the first study analyzing predictors of mortality in COVID-19 patients attended in a private tertiary hospital in Mexico.
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spelling pubmed-100018712023-03-11 Risk Factors for Mortality of Hospitalized Adult Patients with COVID-19 Pneumonia: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico López-Pérez, Carlos Axel Santa Cruz-Pavlovich, Francisco J. Montiel-Cortés, Juan Eduardo Núñez-Muratalla, Adriana Morán-González, Ruth Bibani Villanueva-Gaona, Ricardo Franco-Mojica, Xochitl Moreno-Sandoval, Denisse Gabriela González-Bañuelos, Joselyn Anacaren López-Pérez, Alan Ulises Flores-González, Marily Grijalva-Ruiz, Cristina Valdez-Mendoza, Edna Daniela González-Lucano, Luis Renee López-Zendejas, Martín Int J Environ Res Public Health Article During the COVID-19 pandemic, the high prevalence of comorbidities and the disparities between the public and private health subsystems in Mexico substantially contributed to the severe impact of the disease. The objective of this study was to evaluate and compare the risk factors at admission for in-hospital mortality of patients with COVID-19. A 2-year retrospective cohort study of hospitalized adult patients with COVID-19 pneumonia was conducted at a private tertiary care center. The study population consisted of 1258 patients with a median age of 56 ± 16.5 years, of whom 1093 recovered (86.8%) and 165 died (13.1%). In the univariate analysis, older age (p < 0.001), comorbidities such as hypertension (p < 0.001) and diabetes (p < 0.001), signs and symptoms of respiratory distress, and markers of acute inflammatory response were significantly more frequent in non-survivors. The multivariate analysis showed that older age (p < 0.001), the presence of cyanosis (p = 0.005), and previous myocardial infarction (p = 0.032) were independent predictors of mortality. In the studied cohort, the risk factors present at admission associated with increased mortality were older age, cyanosis, and a previous myocardial infarction, which can be used as valuable predictors for patients’ outcomes. To our knowledge, this is the first study analyzing predictors of mortality in COVID-19 patients attended in a private tertiary hospital in Mexico. MDPI 2023-03-02 /pmc/articles/PMC10001871/ /pubmed/36901460 http://dx.doi.org/10.3390/ijerph20054450 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
López-Pérez, Carlos Axel
Santa Cruz-Pavlovich, Francisco J.
Montiel-Cortés, Juan Eduardo
Núñez-Muratalla, Adriana
Morán-González, Ruth Bibani
Villanueva-Gaona, Ricardo
Franco-Mojica, Xochitl
Moreno-Sandoval, Denisse Gabriela
González-Bañuelos, Joselyn Anacaren
López-Pérez, Alan Ulises
Flores-González, Marily
Grijalva-Ruiz, Cristina
Valdez-Mendoza, Edna Daniela
González-Lucano, Luis Renee
López-Zendejas, Martín
Risk Factors for Mortality of Hospitalized Adult Patients with COVID-19 Pneumonia: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico
title Risk Factors for Mortality of Hospitalized Adult Patients with COVID-19 Pneumonia: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico
title_full Risk Factors for Mortality of Hospitalized Adult Patients with COVID-19 Pneumonia: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico
title_fullStr Risk Factors for Mortality of Hospitalized Adult Patients with COVID-19 Pneumonia: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico
title_full_unstemmed Risk Factors for Mortality of Hospitalized Adult Patients with COVID-19 Pneumonia: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico
title_short Risk Factors for Mortality of Hospitalized Adult Patients with COVID-19 Pneumonia: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico
title_sort risk factors for mortality of hospitalized adult patients with covid-19 pneumonia: a two-year cohort study in a private tertiary care center in mexico
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001871/
https://www.ncbi.nlm.nih.gov/pubmed/36901460
http://dx.doi.org/10.3390/ijerph20054450
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