Discovery-Based Proteomics Identify Skeletal Muscle Mitochondrial Alterations as an Early Metabolic Defect in a Mouse Model of β-Thalassemia

Although metabolic complications are common in thalassemia patients, there is still an unmet need to better understand underlying mechanisms. We used unbiased global proteomics to reveal molecular differences between the th(3/+) mouse model of thalassemia and wild-type control animals focusing on sk...

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Detalles Bibliográficos
Autores principales: Reboucas, Patricia, Fillebeen, Carine, Botta, Amy, Cleverdon, Riley, Steele, Alexandra P., Richard, Vincent, Zahedi, René P., Borchers, Christoph H., Burelle, Yan, Hawke, Thomas J., Pantopoulos, Kostas, Sweeney, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002226/
https://www.ncbi.nlm.nih.gov/pubmed/36901833
http://dx.doi.org/10.3390/ijms24054402

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