Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth

The activation of Wnt/β-catenin signalling is a prerequisite for odontogenesis. APC, a member of the AXIN-CK1-GSK3β-APC β-catenin destruction complex, functions to modulate Wnt/β-catenin signalling to establish regular teeth number and positions. APC loss-of-function mutations are associated with th...

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Detalles Bibliográficos
Autores principales: Panyarat, Chomchanok, Nakornchai, Siriruk, Chintakanon, Kanoknart, Leelaadisorn, Niramol, Intachai, Worrachet, Olsen, Bjorn, Tongsima, Sissades, Adisornkanj, Ploy, Ngamphiw, Chumpol, Cox, Timothy C., Kantaputra, Piranit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002335/
https://www.ncbi.nlm.nih.gov/pubmed/36901686
http://dx.doi.org/10.3390/ijms24054255

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