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The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status
Excess iron is known to trigger adipose tissue dysfunction and insulin resistance. Circulating markers of iron status have been associated with obesity and adipose tissue in cross-sectional studies. We aimed to evaluate whether iron status is linked to changes in abdominal adipose tissue longitudina...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002479/ https://www.ncbi.nlm.nih.gov/pubmed/36902180 http://dx.doi.org/10.3390/ijms24054750 |
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author | Hinojosa-Moscoso, Alejandro Motger-Albertí, Anna De la Calle-Vargas, Elena Martí-Navas, Marian Biarnés, Carles Arnoriaga-Rodríguez, María Blasco, Gerard Puig, Josep Luque-Córdoba, Diego Priego-Capote, Feliciano Moreno-Navarrete, José María Fernández-Real, José Manuel |
author_facet | Hinojosa-Moscoso, Alejandro Motger-Albertí, Anna De la Calle-Vargas, Elena Martí-Navas, Marian Biarnés, Carles Arnoriaga-Rodríguez, María Blasco, Gerard Puig, Josep Luque-Córdoba, Diego Priego-Capote, Feliciano Moreno-Navarrete, José María Fernández-Real, José Manuel |
author_sort | Hinojosa-Moscoso, Alejandro |
collection | PubMed |
description | Excess iron is known to trigger adipose tissue dysfunction and insulin resistance. Circulating markers of iron status have been associated with obesity and adipose tissue in cross-sectional studies. We aimed to evaluate whether iron status is linked to changes in abdominal adipose tissue longitudinally. Subcutaneous abdominal tissue (SAT) and visceral adipose tissue (VAT) and its quotient (pSAT) were assessed using magnetic resonance imaging (MRI), at baseline and after one year of follow-up, in 131 (79 in follow-up) apparently healthy subjects, with and without obesity. Insulin sensitivity (euglycemic– hyperinsulinemic clamp) and markers of iron status were also evaluated. Baseline serum hepcidin (p = 0.005 and p = 0.002) and ferritin (p = 0.02 and p = 0.01)) were associated with an increase in VAT and SAT over one year in all subjects, while serum transferrin (p = 0.01 and p = 0.03) and total iron-binding capacity (p = 0.02 and p = 0.04) were negatively associated. These associations were mainly observed in women and in subjects without obesity, and were independent of insulin sensitivity. After controlling for age and sex, serum hepcidin was significantly associated with changes in subcutaneous abdominal tissue index (iSAT) (β = 0.406, p = 0.007) and visceral adipose tissue index (iVAT) (β = 0.306, p = 0.04), while changes in insulin sensitivity (β = 0.287, p = 0.03) and fasting triglycerides (β = −0.285, p = 0.03) were associated with changes in pSAT. These data indicated that serum hepcidin are associated with longitudinal changes in SAT and VAT, independently of insulin sensitivity. This would be the first prospective study evaluating the redistribution of fat according to iron status and chronic inflammation. |
format | Online Article Text |
id | pubmed-10002479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100024792023-03-11 The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status Hinojosa-Moscoso, Alejandro Motger-Albertí, Anna De la Calle-Vargas, Elena Martí-Navas, Marian Biarnés, Carles Arnoriaga-Rodríguez, María Blasco, Gerard Puig, Josep Luque-Córdoba, Diego Priego-Capote, Feliciano Moreno-Navarrete, José María Fernández-Real, José Manuel Int J Mol Sci Article Excess iron is known to trigger adipose tissue dysfunction and insulin resistance. Circulating markers of iron status have been associated with obesity and adipose tissue in cross-sectional studies. We aimed to evaluate whether iron status is linked to changes in abdominal adipose tissue longitudinally. Subcutaneous abdominal tissue (SAT) and visceral adipose tissue (VAT) and its quotient (pSAT) were assessed using magnetic resonance imaging (MRI), at baseline and after one year of follow-up, in 131 (79 in follow-up) apparently healthy subjects, with and without obesity. Insulin sensitivity (euglycemic– hyperinsulinemic clamp) and markers of iron status were also evaluated. Baseline serum hepcidin (p = 0.005 and p = 0.002) and ferritin (p = 0.02 and p = 0.01)) were associated with an increase in VAT and SAT over one year in all subjects, while serum transferrin (p = 0.01 and p = 0.03) and total iron-binding capacity (p = 0.02 and p = 0.04) were negatively associated. These associations were mainly observed in women and in subjects without obesity, and were independent of insulin sensitivity. After controlling for age and sex, serum hepcidin was significantly associated with changes in subcutaneous abdominal tissue index (iSAT) (β = 0.406, p = 0.007) and visceral adipose tissue index (iVAT) (β = 0.306, p = 0.04), while changes in insulin sensitivity (β = 0.287, p = 0.03) and fasting triglycerides (β = −0.285, p = 0.03) were associated with changes in pSAT. These data indicated that serum hepcidin are associated with longitudinal changes in SAT and VAT, independently of insulin sensitivity. This would be the first prospective study evaluating the redistribution of fat according to iron status and chronic inflammation. MDPI 2023-03-01 /pmc/articles/PMC10002479/ /pubmed/36902180 http://dx.doi.org/10.3390/ijms24054750 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hinojosa-Moscoso, Alejandro Motger-Albertí, Anna De la Calle-Vargas, Elena Martí-Navas, Marian Biarnés, Carles Arnoriaga-Rodríguez, María Blasco, Gerard Puig, Josep Luque-Córdoba, Diego Priego-Capote, Feliciano Moreno-Navarrete, José María Fernández-Real, José Manuel The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status |
title | The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status |
title_full | The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status |
title_fullStr | The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status |
title_full_unstemmed | The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status |
title_short | The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status |
title_sort | longitudinal changes in subcutaneous abdominal tissue and visceral adipose tissue volumetries are associated with iron status |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002479/ https://www.ncbi.nlm.nih.gov/pubmed/36902180 http://dx.doi.org/10.3390/ijms24054750 |
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