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A Novel Hyaluronic Acid Matrix Ingredient with Regenerative, Anti-Aging and Antioxidant Capacity

Hyaluronic acid (HA) and proteoglycans (such as dermatan sulphate (DS) and chondroitin sulphate (CS)) are the main components of the extracellular matrix of the skin, along with collagen and elastin. These components decrease with age, which implies a loss of skin moisture causing wrinkles, sagging...

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Autores principales: Galvez-Martin, Patricia, Soto-Fernandez, Cristina, Romero-Rueda, Jessica, Cabañas, Jesus, Torrent, Anna, Castells, Gloria, Martinez-Puig, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002543/
https://www.ncbi.nlm.nih.gov/pubmed/36902203
http://dx.doi.org/10.3390/ijms24054774
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author Galvez-Martin, Patricia
Soto-Fernandez, Cristina
Romero-Rueda, Jessica
Cabañas, Jesus
Torrent, Anna
Castells, Gloria
Martinez-Puig, Daniel
author_facet Galvez-Martin, Patricia
Soto-Fernandez, Cristina
Romero-Rueda, Jessica
Cabañas, Jesus
Torrent, Anna
Castells, Gloria
Martinez-Puig, Daniel
author_sort Galvez-Martin, Patricia
collection PubMed
description Hyaluronic acid (HA) and proteoglycans (such as dermatan sulphate (DS) and chondroitin sulphate (CS)) are the main components of the extracellular matrix of the skin, along with collagen and elastin. These components decrease with age, which implies a loss of skin moisture causing wrinkles, sagging and aging. Currently, the external and internal administration of effective ingredients that can reach the epidermis and dermis is the main alternative for combating skin aging. The objective of this work was to extract, characterise and evaluate the potential of an HA matrix ingredient to support anti-aging. The HA matrix was isolated and purified from rooster comb and characterised physicochemically and molecularly. In addition, its regenerative, anti-aging and antioxidant potential and intestinal absorption were evaluated. The results show that the HA matrix is composed of 67% HA, with an average molecular weight of 1.3 MDa; 12% sulphated glycosaminoglycans, including DS and CS; 17% protein, including collagen (10.4%); and water. The in vitro evaluation of the HA matrix’s biological activity showed regenerative properties in both fibroblasts and keratinocytes, as well as moisturising, anti-aging and antioxidant effects. Furthermore, the results suggest that the HA matrix could be absorbed in the intestine, implying a potential oral as well as topical use for skin care, either as an ingredient in a nutraceutical or a cosmetic product.
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spelling pubmed-100025432023-03-11 A Novel Hyaluronic Acid Matrix Ingredient with Regenerative, Anti-Aging and Antioxidant Capacity Galvez-Martin, Patricia Soto-Fernandez, Cristina Romero-Rueda, Jessica Cabañas, Jesus Torrent, Anna Castells, Gloria Martinez-Puig, Daniel Int J Mol Sci Article Hyaluronic acid (HA) and proteoglycans (such as dermatan sulphate (DS) and chondroitin sulphate (CS)) are the main components of the extracellular matrix of the skin, along with collagen and elastin. These components decrease with age, which implies a loss of skin moisture causing wrinkles, sagging and aging. Currently, the external and internal administration of effective ingredients that can reach the epidermis and dermis is the main alternative for combating skin aging. The objective of this work was to extract, characterise and evaluate the potential of an HA matrix ingredient to support anti-aging. The HA matrix was isolated and purified from rooster comb and characterised physicochemically and molecularly. In addition, its regenerative, anti-aging and antioxidant potential and intestinal absorption were evaluated. The results show that the HA matrix is composed of 67% HA, with an average molecular weight of 1.3 MDa; 12% sulphated glycosaminoglycans, including DS and CS; 17% protein, including collagen (10.4%); and water. The in vitro evaluation of the HA matrix’s biological activity showed regenerative properties in both fibroblasts and keratinocytes, as well as moisturising, anti-aging and antioxidant effects. Furthermore, the results suggest that the HA matrix could be absorbed in the intestine, implying a potential oral as well as topical use for skin care, either as an ingredient in a nutraceutical or a cosmetic product. MDPI 2023-03-01 /pmc/articles/PMC10002543/ /pubmed/36902203 http://dx.doi.org/10.3390/ijms24054774 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Galvez-Martin, Patricia
Soto-Fernandez, Cristina
Romero-Rueda, Jessica
Cabañas, Jesus
Torrent, Anna
Castells, Gloria
Martinez-Puig, Daniel
A Novel Hyaluronic Acid Matrix Ingredient with Regenerative, Anti-Aging and Antioxidant Capacity
title A Novel Hyaluronic Acid Matrix Ingredient with Regenerative, Anti-Aging and Antioxidant Capacity
title_full A Novel Hyaluronic Acid Matrix Ingredient with Regenerative, Anti-Aging and Antioxidant Capacity
title_fullStr A Novel Hyaluronic Acid Matrix Ingredient with Regenerative, Anti-Aging and Antioxidant Capacity
title_full_unstemmed A Novel Hyaluronic Acid Matrix Ingredient with Regenerative, Anti-Aging and Antioxidant Capacity
title_short A Novel Hyaluronic Acid Matrix Ingredient with Regenerative, Anti-Aging and Antioxidant Capacity
title_sort novel hyaluronic acid matrix ingredient with regenerative, anti-aging and antioxidant capacity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002543/
https://www.ncbi.nlm.nih.gov/pubmed/36902203
http://dx.doi.org/10.3390/ijms24054774
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