A Mouse Systems Genetics Approach Reveals Common and Uncommon Genetic Modifiers of Hepatic Lysosomal Enzyme Activities and Glycosphingolipids

Identification of genetic modulators of lysosomal enzyme activities and glycosphingolipids (GSLs) may facilitate the development of therapeutics for diseases in which they participate, including Lysosomal Storage Disorders (LSDs). To this end, we used a systems genetics approach: we measured 11 hepa...

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Detalles Bibliográficos
Autores principales: Durán, Anyelo, Priestman, David A., Las Heras, Macarena, Rebolledo-Jaramillo, Boris, Olguín, Valeria, Calderón, Juan F., Zanlungo, Silvana, Gutiérrez, Jaime, Platt, Frances M., Klein, Andrés D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002577/
https://www.ncbi.nlm.nih.gov/pubmed/36902345
http://dx.doi.org/10.3390/ijms24054915

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