Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options

Mycobacterium abscessus is an opportunistic pathogen that mainly colonizes and infects cystic fibrosis patients’ lungs. M. abscessus is naturally resistant to many antibiotics such as rifamycin, tetracyclines and β-lactams. The current therapeutic regimens are not very effective and are mostly based...

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Autores principales: Recchia, Deborah, Stelitano, Giovanni, Stamilla, Alessandro, Gutierrez, Damaris L., Degiacomi, Giulia, Chiarelli, Laurent R., Pasca, Maria Rosalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002592/
https://www.ncbi.nlm.nih.gov/pubmed/36902066
http://dx.doi.org/10.3390/ijms24054635
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author Recchia, Deborah
Stelitano, Giovanni
Stamilla, Alessandro
Gutierrez, Damaris L.
Degiacomi, Giulia
Chiarelli, Laurent R.
Pasca, Maria Rosalia
author_facet Recchia, Deborah
Stelitano, Giovanni
Stamilla, Alessandro
Gutierrez, Damaris L.
Degiacomi, Giulia
Chiarelli, Laurent R.
Pasca, Maria Rosalia
author_sort Recchia, Deborah
collection PubMed
description Mycobacterium abscessus is an opportunistic pathogen that mainly colonizes and infects cystic fibrosis patients’ lungs. M. abscessus is naturally resistant to many antibiotics such as rifamycin, tetracyclines and β-lactams. The current therapeutic regimens are not very effective and are mostly based on repurposed drugs used against Mycobacterium tuberculosis infections. Thus, new approaches and novel strategies are urgently needed. This review aims to provide an overview of the latest ongoing findings to fight M. abscessus infections by analyzing emerging and alternative treatments, novel drug delivery strategies, and innovative molecules.
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spelling pubmed-100025922023-03-11 Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options Recchia, Deborah Stelitano, Giovanni Stamilla, Alessandro Gutierrez, Damaris L. Degiacomi, Giulia Chiarelli, Laurent R. Pasca, Maria Rosalia Int J Mol Sci Review Mycobacterium abscessus is an opportunistic pathogen that mainly colonizes and infects cystic fibrosis patients’ lungs. M. abscessus is naturally resistant to many antibiotics such as rifamycin, tetracyclines and β-lactams. The current therapeutic regimens are not very effective and are mostly based on repurposed drugs used against Mycobacterium tuberculosis infections. Thus, new approaches and novel strategies are urgently needed. This review aims to provide an overview of the latest ongoing findings to fight M. abscessus infections by analyzing emerging and alternative treatments, novel drug delivery strategies, and innovative molecules. MDPI 2023-02-27 /pmc/articles/PMC10002592/ /pubmed/36902066 http://dx.doi.org/10.3390/ijms24054635 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Recchia, Deborah
Stelitano, Giovanni
Stamilla, Alessandro
Gutierrez, Damaris L.
Degiacomi, Giulia
Chiarelli, Laurent R.
Pasca, Maria Rosalia
Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options
title Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options
title_full Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options
title_fullStr Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options
title_full_unstemmed Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options
title_short Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options
title_sort mycobacterium abscessus infections in cystic fibrosis individuals: a review on therapeutic options
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002592/
https://www.ncbi.nlm.nih.gov/pubmed/36902066
http://dx.doi.org/10.3390/ijms24054635
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