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FREEDA: an automated computational pipeline guides experimental testing of protein innovation by detecting positive selection
Cell biologists typically focus on conserved regions of a protein, overlooking innovations that can shape its function over evolutionary time. Computational analyses can reveal potential innovations by detecting statistical signatures of positive selection that leads to rapid accumulation of benefic...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002610/ https://www.ncbi.nlm.nih.gov/pubmed/36909479 http://dx.doi.org/10.1101/2023.02.27.530329 |