Rapid resistance profiling of SARS-CoV-2 protease inhibitors

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Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a panel of SARS-CoV-2 main protease (M(pro)) variants and a robust cell-based assay are used to compare the resistance profiles of nirmatrelvir, ensitrelvir, and FB2001...

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Autores principales: Moghadasi, Seyed Arad, Biswas, Rayhan G., Harki, Daniel A., Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002627/
https://www.ncbi.nlm.nih.gov/pubmed/36909573
http://dx.doi.org/10.1101/2023.02.25.530000
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author Moghadasi, Seyed Arad
Biswas, Rayhan G.
Harki, Daniel A.
Harris, Reuben S.
author_facet Moghadasi, Seyed Arad
Biswas, Rayhan G.
Harki, Daniel A.
Harris, Reuben S.
author_sort Moghadasi, Seyed Arad
collection PubMed
description Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a panel of SARS-CoV-2 main protease (M(pro)) variants and a robust cell-based assay are used to compare the resistance profiles of nirmatrelvir, ensitrelvir, and FB2001. The results reveal distinct resistance mechanisms (“fingerprints”) and indicate that these next-generation drugs have the potential to be effective against nirmatrelvir-resistant variants and vice versa.
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spelling pubmed-100026272023-03-11 Rapid resistance profiling of SARS-CoV-2 protease inhibitors Moghadasi, Seyed Arad Biswas, Rayhan G. Harki, Daniel A. Harris, Reuben S. bioRxiv Article Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a panel of SARS-CoV-2 main protease (M(pro)) variants and a robust cell-based assay are used to compare the resistance profiles of nirmatrelvir, ensitrelvir, and FB2001. The results reveal distinct resistance mechanisms (“fingerprints”) and indicate that these next-generation drugs have the potential to be effective against nirmatrelvir-resistant variants and vice versa. Cold Spring Harbor Laboratory 2023-02-27 /pmc/articles/PMC10002627/ /pubmed/36909573 http://dx.doi.org/10.1101/2023.02.25.530000 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Moghadasi, Seyed Arad
Biswas, Rayhan G.
Harki, Daniel A.
Harris, Reuben S.
Rapid resistance profiling of SARS-CoV-2 protease inhibitors
title Rapid resistance profiling of SARS-CoV-2 protease inhibitors
title_full Rapid resistance profiling of SARS-CoV-2 protease inhibitors
title_fullStr Rapid resistance profiling of SARS-CoV-2 protease inhibitors
title_full_unstemmed Rapid resistance profiling of SARS-CoV-2 protease inhibitors
title_short Rapid resistance profiling of SARS-CoV-2 protease inhibitors
title_sort rapid resistance profiling of sars-cov-2 protease inhibitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002627/
https://www.ncbi.nlm.nih.gov/pubmed/36909573
http://dx.doi.org/10.1101/2023.02.25.530000
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