FOXP3(+) regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues

FOXP3(+) regulatory T cells (Treg) depend on exogenous IL-2 for their survival and function, but circulating levels of IL-2 are low, making it unclear how Treg access this critical resource in vivo. Here, we show that Treg use heparanase (HPSE) to access IL-2 sequestered by heparan sulfate (HS) with...

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Detalles Bibliográficos
Autores principales: Martinez, Hunter A., Koliesnik, Ievgen, Kaber, Gernot, Reid, Jacqueline K., Nagy, Nadine, Barlow, Graham, Falk, Ben A., Medina, Carlos O., Hargil, Aviv, Vlodavsky, Israel, Li, Jin-Ping, Pérez-Cruz, Magdiel, Tang, Sai-Wen, Meyer, Everett H., Wrenshall, Lucile E., Lord, James D., Garcia, K. Christopher, Palmer, Theo D., Steinman, Lawrence, Nepom, Gerald T., Wight, Thomas N., Bollyky, Paul L., Kuipers, Hedwich F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002643/
https://www.ncbi.nlm.nih.gov/pubmed/36909599
http://dx.doi.org/10.1101/2023.02.26.529772

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