Mdm2/p53 levels in bone marrow mesenchymal stromal cells Is essential for maintaining the hematopoietic niche in response to DNA damage

Mesenchymal stromal cells (MSCs) are a key component of the bone marrow (BM) niche, providing essential support required for maintenance of hematopoietic stem cells. To advance our understanding of physiological functions of p53 and Mdm2 in BM-MSCs, we developed traceable conditional mouse models ta...

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Detalles Bibliográficos
Autores principales: Pourebrahim, Rasoul, Montoya, Rafael Heinz, Alaniz, Zoe, Ostermann, Lauren, Lin, Patrick P., Liu, Bin, Ayoub, Edward, Burks, Jared K., Andreeff, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002809/
https://www.ncbi.nlm.nih.gov/pubmed/36909480
http://dx.doi.org/10.21203/rs.3.rs-2544760/v1

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