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Insertion Depth Modulates Protein Kinase C-δ-C1b Domain Interactions with Membrane Cholesterol as Revealed by MD Simulations

Protein kinase C delta (PKC-δ) is an important signaling molecule in human cells that has both proapoptotic as well as antiapoptotic functions. These conflicting activities can be modulated by two classes of ligands, phorbol esters and bryostatins. Phorbol esters are known tumor promoters, while bry...

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Detalles Bibliográficos
Autores principales:	Judge, Patrick T., Overall, Sarah A., Barnes, Alexander B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002858/ https://www.ncbi.nlm.nih.gov/pubmed/36902029 http://dx.doi.org/10.3390/ijms24054598

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