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Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study
Objective: The aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and to evaluate their potential impact on ICSI outcomes. Materials and Methods: It is a prospective case-control study conducted on 25 women with proven endometriosis and 5...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002901/ https://www.ncbi.nlm.nih.gov/pubmed/36902616 http://dx.doi.org/10.3390/jcm12051829 |
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author | Kacem-Berjeb, Khadija Braham, Marouen Massoud, Cyrine Ben Hannachi, Hela Hamdoun, Manel Chtourou, Sana Debbabi, Linda Bouyahia, Maha Fadhlaoui, Anis Zhioua, Fethi Feki, Anis Chakroun, Nozha Bahri, Olfa |
author_facet | Kacem-Berjeb, Khadija Braham, Marouen Massoud, Cyrine Ben Hannachi, Hela Hamdoun, Manel Chtourou, Sana Debbabi, Linda Bouyahia, Maha Fadhlaoui, Anis Zhioua, Fethi Feki, Anis Chakroun, Nozha Bahri, Olfa |
author_sort | Kacem-Berjeb, Khadija |
collection | PubMed |
description | Objective: The aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and to evaluate their potential impact on ICSI outcomes. Materials and Methods: It is a prospective case-control study conducted on 25 women with proven endometriosis and 50 patients diagnosed with other causes of infertility. All these patients were candidates for ICSI cycles. Their follicular fluid was collected at the time of oocyte retrieval and used to evaluate IL-6 and AMH titers by electro-chemiluminescent immunoassay (Cobas e411-Roche). Results: The IL-6 levels in follicular fluid were higher in the endometriosis group than in the control group (152.3 vs. 19.9 pg/mL; p = 0.02). The median level for AMH was 2.2 ± 1.88 ng/mL with no statistical difference between the two groups (2.2 vs. 2.7 ng/mL, p = 0.41). No significant correlation between the follicular IL6 and AMH levels was observed. Conclusions: The oocyte quality seems to be preserved in patients with endometriosis with the adequate response to ovarian stimulation. High levels of follicular IL6 are in accordance with the inflammatory phenomenon of the disease; however, this increase has no impact on ICSI outcomes. |
format | Online Article Text |
id | pubmed-10002901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100029012023-03-11 Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study Kacem-Berjeb, Khadija Braham, Marouen Massoud, Cyrine Ben Hannachi, Hela Hamdoun, Manel Chtourou, Sana Debbabi, Linda Bouyahia, Maha Fadhlaoui, Anis Zhioua, Fethi Feki, Anis Chakroun, Nozha Bahri, Olfa J Clin Med Article Objective: The aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and to evaluate their potential impact on ICSI outcomes. Materials and Methods: It is a prospective case-control study conducted on 25 women with proven endometriosis and 50 patients diagnosed with other causes of infertility. All these patients were candidates for ICSI cycles. Their follicular fluid was collected at the time of oocyte retrieval and used to evaluate IL-6 and AMH titers by electro-chemiluminescent immunoassay (Cobas e411-Roche). Results: The IL-6 levels in follicular fluid were higher in the endometriosis group than in the control group (152.3 vs. 19.9 pg/mL; p = 0.02). The median level for AMH was 2.2 ± 1.88 ng/mL with no statistical difference between the two groups (2.2 vs. 2.7 ng/mL, p = 0.41). No significant correlation between the follicular IL6 and AMH levels was observed. Conclusions: The oocyte quality seems to be preserved in patients with endometriosis with the adequate response to ovarian stimulation. High levels of follicular IL6 are in accordance with the inflammatory phenomenon of the disease; however, this increase has no impact on ICSI outcomes. MDPI 2023-02-24 /pmc/articles/PMC10002901/ /pubmed/36902616 http://dx.doi.org/10.3390/jcm12051829 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kacem-Berjeb, Khadija Braham, Marouen Massoud, Cyrine Ben Hannachi, Hela Hamdoun, Manel Chtourou, Sana Debbabi, Linda Bouyahia, Maha Fadhlaoui, Anis Zhioua, Fethi Feki, Anis Chakroun, Nozha Bahri, Olfa Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study |
title | Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study |
title_full | Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study |
title_fullStr | Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study |
title_full_unstemmed | Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study |
title_short | Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study |
title_sort | does endometriosis impact the composition of follicular fluid in il6 and amh? a case-control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002901/ https://www.ncbi.nlm.nih.gov/pubmed/36902616 http://dx.doi.org/10.3390/jcm12051829 |
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