Cargando…
Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism
Pulmonary embolism (PE) is a potentially life-threatening disorder. Beyond its usefulness in the prognostic stratification of heart failure, sST2 can represent a biomarker with high utility in several acute conditions. Our study was aimed to investigate whether sST2 can be used as a clinical marker...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002919/ https://www.ncbi.nlm.nih.gov/pubmed/36902022 http://dx.doi.org/10.3390/ijms24054591 |
_version_ | 1784904485599969280 |
---|---|
author | Petramala, Luigi Concistrè, Antonio Sarlo, Francesca Baroni, Silvia Suppa, Marianna Servello, Adriana Circosta, Francesco Galardo, Gioacchino Gandini, Orietta Marino, Luca Cavallaro, Giuseppe Iannucci, Gino Letizia, Claudio |
author_facet | Petramala, Luigi Concistrè, Antonio Sarlo, Francesca Baroni, Silvia Suppa, Marianna Servello, Adriana Circosta, Francesco Galardo, Gioacchino Gandini, Orietta Marino, Luca Cavallaro, Giuseppe Iannucci, Gino Letizia, Claudio |
author_sort | Petramala, Luigi |
collection | PubMed |
description | Pulmonary embolism (PE) is a potentially life-threatening disorder. Beyond its usefulness in the prognostic stratification of heart failure, sST2 can represent a biomarker with high utility in several acute conditions. Our study was aimed to investigate whether sST2 can be used as a clinical marker of severity and prognostic outcome in acute PE. We enrolled 72 patients with documented PE and 38 healthy subjects; we measured the plasma concentrations of sST2 to evaluate the prognostic and severity performance of different levels of sST2 according to its association with the pulmonary embolism severity index (PESI) score and several parameters of respiratory function. PE patients had significantly higher levels of sST2 compared with healthy subjects (87.74 ± 17.1 vs. 17.1 ± 0.4 ng/mL, p < 0.001); we found higher PESI scores and serum lactate values in the group of patients with sST2 > 35 ng/mL compared with patients with sST2 < 35 ng/mL (138.7 ± 14.9 vs. 103.7 ± 15.1 and 2.43 ± 0.69 vs. 1.025 ± 0.05 mmol/L, respectively; p < 0.05). Patients with sST2 > 35 ng/mL showed higher radiological severity of PE compared with patients with sST2 < 35 ng/mL. Moreover, sST2 was the strongest parameter with a discriminative capacity for the development of acute respiratory failure and a PESI score >106 with respect to C reactive protein (CRP), creatinine, d-dimer, and serum lactate. We clearly demonstrated that sST2 significantly increased in PE and that its elevation was associated with disease severity. Therefore, sST2 may be used as a clinical marker in the evaluation of PE severity. However, further studies with larger patient populations are required to confirm these findings. |
format | Online Article Text |
id | pubmed-10002919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100029192023-03-11 Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism Petramala, Luigi Concistrè, Antonio Sarlo, Francesca Baroni, Silvia Suppa, Marianna Servello, Adriana Circosta, Francesco Galardo, Gioacchino Gandini, Orietta Marino, Luca Cavallaro, Giuseppe Iannucci, Gino Letizia, Claudio Int J Mol Sci Article Pulmonary embolism (PE) is a potentially life-threatening disorder. Beyond its usefulness in the prognostic stratification of heart failure, sST2 can represent a biomarker with high utility in several acute conditions. Our study was aimed to investigate whether sST2 can be used as a clinical marker of severity and prognostic outcome in acute PE. We enrolled 72 patients with documented PE and 38 healthy subjects; we measured the plasma concentrations of sST2 to evaluate the prognostic and severity performance of different levels of sST2 according to its association with the pulmonary embolism severity index (PESI) score and several parameters of respiratory function. PE patients had significantly higher levels of sST2 compared with healthy subjects (87.74 ± 17.1 vs. 17.1 ± 0.4 ng/mL, p < 0.001); we found higher PESI scores and serum lactate values in the group of patients with sST2 > 35 ng/mL compared with patients with sST2 < 35 ng/mL (138.7 ± 14.9 vs. 103.7 ± 15.1 and 2.43 ± 0.69 vs. 1.025 ± 0.05 mmol/L, respectively; p < 0.05). Patients with sST2 > 35 ng/mL showed higher radiological severity of PE compared with patients with sST2 < 35 ng/mL. Moreover, sST2 was the strongest parameter with a discriminative capacity for the development of acute respiratory failure and a PESI score >106 with respect to C reactive protein (CRP), creatinine, d-dimer, and serum lactate. We clearly demonstrated that sST2 significantly increased in PE and that its elevation was associated with disease severity. Therefore, sST2 may be used as a clinical marker in the evaluation of PE severity. However, further studies with larger patient populations are required to confirm these findings. MDPI 2023-02-27 /pmc/articles/PMC10002919/ /pubmed/36902022 http://dx.doi.org/10.3390/ijms24054591 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Petramala, Luigi Concistrè, Antonio Sarlo, Francesca Baroni, Silvia Suppa, Marianna Servello, Adriana Circosta, Francesco Galardo, Gioacchino Gandini, Orietta Marino, Luca Cavallaro, Giuseppe Iannucci, Gino Letizia, Claudio Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism |
title | Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism |
title_full | Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism |
title_fullStr | Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism |
title_full_unstemmed | Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism |
title_short | Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism |
title_sort | assessment of sst2 behaviors to evaluate severity/clinical impact of acute pulmonary embolism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002919/ https://www.ncbi.nlm.nih.gov/pubmed/36902022 http://dx.doi.org/10.3390/ijms24054591 |
work_keys_str_mv | AT petramalaluigi assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism AT concistreantonio assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism AT sarlofrancesca assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism AT baronisilvia assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism AT suppamarianna assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism AT servelloadriana assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism AT circostafrancesco assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism AT galardogioacchino assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism AT gandiniorietta assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism AT marinoluca assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism AT cavallarogiuseppe assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism AT iannuccigino assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism AT letiziaclaudio assessmentofsst2behaviorstoevaluateseverityclinicalimpactofacutepulmonaryembolism |