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Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism

Pulmonary embolism (PE) is a potentially life-threatening disorder. Beyond its usefulness in the prognostic stratification of heart failure, sST2 can represent a biomarker with high utility in several acute conditions. Our study was aimed to investigate whether sST2 can be used as a clinical marker...

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Autores principales: Petramala, Luigi, Concistrè, Antonio, Sarlo, Francesca, Baroni, Silvia, Suppa, Marianna, Servello, Adriana, Circosta, Francesco, Galardo, Gioacchino, Gandini, Orietta, Marino, Luca, Cavallaro, Giuseppe, Iannucci, Gino, Letizia, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002919/
https://www.ncbi.nlm.nih.gov/pubmed/36902022
http://dx.doi.org/10.3390/ijms24054591
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author Petramala, Luigi
Concistrè, Antonio
Sarlo, Francesca
Baroni, Silvia
Suppa, Marianna
Servello, Adriana
Circosta, Francesco
Galardo, Gioacchino
Gandini, Orietta
Marino, Luca
Cavallaro, Giuseppe
Iannucci, Gino
Letizia, Claudio
author_facet Petramala, Luigi
Concistrè, Antonio
Sarlo, Francesca
Baroni, Silvia
Suppa, Marianna
Servello, Adriana
Circosta, Francesco
Galardo, Gioacchino
Gandini, Orietta
Marino, Luca
Cavallaro, Giuseppe
Iannucci, Gino
Letizia, Claudio
author_sort Petramala, Luigi
collection PubMed
description Pulmonary embolism (PE) is a potentially life-threatening disorder. Beyond its usefulness in the prognostic stratification of heart failure, sST2 can represent a biomarker with high utility in several acute conditions. Our study was aimed to investigate whether sST2 can be used as a clinical marker of severity and prognostic outcome in acute PE. We enrolled 72 patients with documented PE and 38 healthy subjects; we measured the plasma concentrations of sST2 to evaluate the prognostic and severity performance of different levels of sST2 according to its association with the pulmonary embolism severity index (PESI) score and several parameters of respiratory function. PE patients had significantly higher levels of sST2 compared with healthy subjects (87.74 ± 17.1 vs. 17.1 ± 0.4 ng/mL, p < 0.001); we found higher PESI scores and serum lactate values in the group of patients with sST2 > 35 ng/mL compared with patients with sST2 < 35 ng/mL (138.7 ± 14.9 vs. 103.7 ± 15.1 and 2.43 ± 0.69 vs. 1.025 ± 0.05 mmol/L, respectively; p < 0.05). Patients with sST2 > 35 ng/mL showed higher radiological severity of PE compared with patients with sST2 < 35 ng/mL. Moreover, sST2 was the strongest parameter with a discriminative capacity for the development of acute respiratory failure and a PESI score >106 with respect to C reactive protein (CRP), creatinine, d-dimer, and serum lactate. We clearly demonstrated that sST2 significantly increased in PE and that its elevation was associated with disease severity. Therefore, sST2 may be used as a clinical marker in the evaluation of PE severity. However, further studies with larger patient populations are required to confirm these findings.
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spelling pubmed-100029192023-03-11 Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism Petramala, Luigi Concistrè, Antonio Sarlo, Francesca Baroni, Silvia Suppa, Marianna Servello, Adriana Circosta, Francesco Galardo, Gioacchino Gandini, Orietta Marino, Luca Cavallaro, Giuseppe Iannucci, Gino Letizia, Claudio Int J Mol Sci Article Pulmonary embolism (PE) is a potentially life-threatening disorder. Beyond its usefulness in the prognostic stratification of heart failure, sST2 can represent a biomarker with high utility in several acute conditions. Our study was aimed to investigate whether sST2 can be used as a clinical marker of severity and prognostic outcome in acute PE. We enrolled 72 patients with documented PE and 38 healthy subjects; we measured the plasma concentrations of sST2 to evaluate the prognostic and severity performance of different levels of sST2 according to its association with the pulmonary embolism severity index (PESI) score and several parameters of respiratory function. PE patients had significantly higher levels of sST2 compared with healthy subjects (87.74 ± 17.1 vs. 17.1 ± 0.4 ng/mL, p < 0.001); we found higher PESI scores and serum lactate values in the group of patients with sST2 > 35 ng/mL compared with patients with sST2 < 35 ng/mL (138.7 ± 14.9 vs. 103.7 ± 15.1 and 2.43 ± 0.69 vs. 1.025 ± 0.05 mmol/L, respectively; p < 0.05). Patients with sST2 > 35 ng/mL showed higher radiological severity of PE compared with patients with sST2 < 35 ng/mL. Moreover, sST2 was the strongest parameter with a discriminative capacity for the development of acute respiratory failure and a PESI score >106 with respect to C reactive protein (CRP), creatinine, d-dimer, and serum lactate. We clearly demonstrated that sST2 significantly increased in PE and that its elevation was associated with disease severity. Therefore, sST2 may be used as a clinical marker in the evaluation of PE severity. However, further studies with larger patient populations are required to confirm these findings. MDPI 2023-02-27 /pmc/articles/PMC10002919/ /pubmed/36902022 http://dx.doi.org/10.3390/ijms24054591 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Petramala, Luigi
Concistrè, Antonio
Sarlo, Francesca
Baroni, Silvia
Suppa, Marianna
Servello, Adriana
Circosta, Francesco
Galardo, Gioacchino
Gandini, Orietta
Marino, Luca
Cavallaro, Giuseppe
Iannucci, Gino
Letizia, Claudio
Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism
title Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism
title_full Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism
title_fullStr Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism
title_full_unstemmed Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism
title_short Assessment of sST2 Behaviors to Evaluate Severity/Clinical Impact of Acute Pulmonary Embolism
title_sort assessment of sst2 behaviors to evaluate severity/clinical impact of acute pulmonary embolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002919/
https://www.ncbi.nlm.nih.gov/pubmed/36902022
http://dx.doi.org/10.3390/ijms24054591
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