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COVID-19 Biogenesis and Intracellular Transport
SARS-CoV-2 is responsible for the COVID-19 pandemic. The structure of SARS-CoV-2 and most of its proteins of have been deciphered. SARS-CoV-2 enters cells through the endocytic pathway and perforates the endosomes’ membranes, and its (+) RNA appears in the cytosol. Then, SARS-CoV-2 starts to use the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002980/ https://www.ncbi.nlm.nih.gov/pubmed/36901955 http://dx.doi.org/10.3390/ijms24054523 |
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author | Mironov, Alexander A. Savin, Maksim A. Beznoussenko, Galina V. |
author_facet | Mironov, Alexander A. Savin, Maksim A. Beznoussenko, Galina V. |
author_sort | Mironov, Alexander A. |
collection | PubMed |
description | SARS-CoV-2 is responsible for the COVID-19 pandemic. The structure of SARS-CoV-2 and most of its proteins of have been deciphered. SARS-CoV-2 enters cells through the endocytic pathway and perforates the endosomes’ membranes, and its (+) RNA appears in the cytosol. Then, SARS-CoV-2 starts to use the protein machines of host cells and their membranes for its biogenesis. SARS-CoV-2 generates a replication organelle in the reticulo-vesicular network of the zippered endoplasmic reticulum and double membrane vesicles. Then, viral proteins start to oligomerize and are subjected to budding within the ER exit sites, and its virions are passed through the Golgi complex, where the proteins are subjected to glycosylation and appear in post-Golgi carriers. After their fusion with the plasma membrane, glycosylated virions are secreted into the lumen of airways or (seemingly rarely) into the space between epithelial cells. This review focuses on the biology of SARS-CoV-2’s interactions with cells and its transport within cells. Our analysis revealed a significant number of unclear points related to intracellular transport in SARS-CoV-2-infected cells. |
format | Online Article Text |
id | pubmed-10002980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100029802023-03-11 COVID-19 Biogenesis and Intracellular Transport Mironov, Alexander A. Savin, Maksim A. Beznoussenko, Galina V. Int J Mol Sci Review SARS-CoV-2 is responsible for the COVID-19 pandemic. The structure of SARS-CoV-2 and most of its proteins of have been deciphered. SARS-CoV-2 enters cells through the endocytic pathway and perforates the endosomes’ membranes, and its (+) RNA appears in the cytosol. Then, SARS-CoV-2 starts to use the protein machines of host cells and their membranes for its biogenesis. SARS-CoV-2 generates a replication organelle in the reticulo-vesicular network of the zippered endoplasmic reticulum and double membrane vesicles. Then, viral proteins start to oligomerize and are subjected to budding within the ER exit sites, and its virions are passed through the Golgi complex, where the proteins are subjected to glycosylation and appear in post-Golgi carriers. After their fusion with the plasma membrane, glycosylated virions are secreted into the lumen of airways or (seemingly rarely) into the space between epithelial cells. This review focuses on the biology of SARS-CoV-2’s interactions with cells and its transport within cells. Our analysis revealed a significant number of unclear points related to intracellular transport in SARS-CoV-2-infected cells. MDPI 2023-02-24 /pmc/articles/PMC10002980/ /pubmed/36901955 http://dx.doi.org/10.3390/ijms24054523 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mironov, Alexander A. Savin, Maksim A. Beznoussenko, Galina V. COVID-19 Biogenesis and Intracellular Transport |
title | COVID-19 Biogenesis and Intracellular Transport |
title_full | COVID-19 Biogenesis and Intracellular Transport |
title_fullStr | COVID-19 Biogenesis and Intracellular Transport |
title_full_unstemmed | COVID-19 Biogenesis and Intracellular Transport |
title_short | COVID-19 Biogenesis and Intracellular Transport |
title_sort | covid-19 biogenesis and intracellular transport |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002980/ https://www.ncbi.nlm.nih.gov/pubmed/36901955 http://dx.doi.org/10.3390/ijms24054523 |
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