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Skin Temperature Circadian Rhythms and Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Role of Endothelin-1 in the Vascular Tone Dysregulation

There is accumulating evidence of autonomic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); however, little is known about its association with circadian rhythms and endothelial dysfunction. This study aimed to explore the autonomic responses through an orthostatic test a...

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Autores principales: Cambras, Trinitat, Zerón-Rugerio, Maria Fernanda, Díez-Noguera, Antoni, Zaragozá, Maria Cleofé, Domingo, Joan Carles, Sanmartin-Sentañes, Ramon, Alegre-Martin, Jose, Castro-Marrero, Jesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003028/
https://www.ncbi.nlm.nih.gov/pubmed/36902264
http://dx.doi.org/10.3390/ijms24054835
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author Cambras, Trinitat
Zerón-Rugerio, Maria Fernanda
Díez-Noguera, Antoni
Zaragozá, Maria Cleofé
Domingo, Joan Carles
Sanmartin-Sentañes, Ramon
Alegre-Martin, Jose
Castro-Marrero, Jesus
author_facet Cambras, Trinitat
Zerón-Rugerio, Maria Fernanda
Díez-Noguera, Antoni
Zaragozá, Maria Cleofé
Domingo, Joan Carles
Sanmartin-Sentañes, Ramon
Alegre-Martin, Jose
Castro-Marrero, Jesus
author_sort Cambras, Trinitat
collection PubMed
description There is accumulating evidence of autonomic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); however, little is known about its association with circadian rhythms and endothelial dysfunction. This study aimed to explore the autonomic responses through an orthostatic test and analysis of the peripheral skin temperature variations and vascular endothelium state in ME/CFS patients. Sixty-seven adult female ME/CFS patients and 48 healthy controls were enrolled. Demographic and clinical characteristics were assessed using validated self-reported outcome measures. Postural changes in blood pressure, heart rate, and wrist temperature were recorded during the orthostatic test. Actigraphy during one week was used to determine the 24-h profile of peripheral temperature and activity. Circulating endothelial biomarkers were measured as indicators of endothelial functioning. Results showed that ME/CFS patients presented higher blood pressure and heart rate values than healthy controls in the supine and standing position (p < 0.05 for both), and also a higher amplitude of the activity rhythm (p < 0.01). Circulating levels of endothelin-1 (ET-1) and vascular cell adhesion molecule-1 (VCAM-1) were significantly higher in ME/CFS (p < 0.05). In ME/CFS, ET-1 levels were associated with the stability of the temperature rhythm (p < 0.01), and also with the self-reported questionnaires (p < 0.001). This suggests that ME/CFS patients exhibited modifications in circadian rhythm and hemodynamic measures, which are associated with endothelial biomarkers (ET-1 and VCAM-1). Future investigation in this area is needed to assess dysautonomia and vascular tone abnormalities, which may provide potential therapeutic targets for ME/CFS.
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spelling pubmed-100030282023-03-11 Skin Temperature Circadian Rhythms and Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Role of Endothelin-1 in the Vascular Tone Dysregulation Cambras, Trinitat Zerón-Rugerio, Maria Fernanda Díez-Noguera, Antoni Zaragozá, Maria Cleofé Domingo, Joan Carles Sanmartin-Sentañes, Ramon Alegre-Martin, Jose Castro-Marrero, Jesus Int J Mol Sci Article There is accumulating evidence of autonomic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); however, little is known about its association with circadian rhythms and endothelial dysfunction. This study aimed to explore the autonomic responses through an orthostatic test and analysis of the peripheral skin temperature variations and vascular endothelium state in ME/CFS patients. Sixty-seven adult female ME/CFS patients and 48 healthy controls were enrolled. Demographic and clinical characteristics were assessed using validated self-reported outcome measures. Postural changes in blood pressure, heart rate, and wrist temperature were recorded during the orthostatic test. Actigraphy during one week was used to determine the 24-h profile of peripheral temperature and activity. Circulating endothelial biomarkers were measured as indicators of endothelial functioning. Results showed that ME/CFS patients presented higher blood pressure and heart rate values than healthy controls in the supine and standing position (p < 0.05 for both), and also a higher amplitude of the activity rhythm (p < 0.01). Circulating levels of endothelin-1 (ET-1) and vascular cell adhesion molecule-1 (VCAM-1) were significantly higher in ME/CFS (p < 0.05). In ME/CFS, ET-1 levels were associated with the stability of the temperature rhythm (p < 0.01), and also with the self-reported questionnaires (p < 0.001). This suggests that ME/CFS patients exhibited modifications in circadian rhythm and hemodynamic measures, which are associated with endothelial biomarkers (ET-1 and VCAM-1). Future investigation in this area is needed to assess dysautonomia and vascular tone abnormalities, which may provide potential therapeutic targets for ME/CFS. MDPI 2023-03-02 /pmc/articles/PMC10003028/ /pubmed/36902264 http://dx.doi.org/10.3390/ijms24054835 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cambras, Trinitat
Zerón-Rugerio, Maria Fernanda
Díez-Noguera, Antoni
Zaragozá, Maria Cleofé
Domingo, Joan Carles
Sanmartin-Sentañes, Ramon
Alegre-Martin, Jose
Castro-Marrero, Jesus
Skin Temperature Circadian Rhythms and Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Role of Endothelin-1 in the Vascular Tone Dysregulation
title Skin Temperature Circadian Rhythms and Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Role of Endothelin-1 in the Vascular Tone Dysregulation
title_full Skin Temperature Circadian Rhythms and Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Role of Endothelin-1 in the Vascular Tone Dysregulation
title_fullStr Skin Temperature Circadian Rhythms and Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Role of Endothelin-1 in the Vascular Tone Dysregulation
title_full_unstemmed Skin Temperature Circadian Rhythms and Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Role of Endothelin-1 in the Vascular Tone Dysregulation
title_short Skin Temperature Circadian Rhythms and Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Role of Endothelin-1 in the Vascular Tone Dysregulation
title_sort skin temperature circadian rhythms and dysautonomia in myalgic encephalomyelitis/chronic fatigue syndrome: the role of endothelin-1 in the vascular tone dysregulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003028/
https://www.ncbi.nlm.nih.gov/pubmed/36902264
http://dx.doi.org/10.3390/ijms24054835
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